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Catalog Number Size Price
LS-B6428-0.1 0.1 ml (1.14 mg/ml) $460 
SDHB Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
SDHB Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
SDHB Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
SDHB Antibody - SDHB Antibody - WB detection of SDHB in mouse kidney lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
SDHB Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
SDHB Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
SDHB Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
SDHB Antibody - SDHB Antibody - WB detection of SDHB in mouse kidney lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PathPlus™ Polyclonal Rabbit anti‑Human SDHB Antibody (aa1‑150, IHC, IF, WB) LS‑B6428

PathPlus™ Polyclonal Rabbit anti‑Human SDHB Antibody (aa1‑150, IHC, IF, WB) LS‑B6428

Note: This antibody replaces LS-C143581
Antibody:
SDHB Rabbit anti-Human Polyclonal (aa1-150) Antibody
Application:
IHC-P, ICC, IF, WB
Reactivity:
Human, Mouse
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$460
LS-B6428-0.1
Toll Free North America
(800) 227-6666
For Research Use Only

Overview

Antibody:
SDHB Rabbit anti-Human Polyclonal (aa1-150) Antibody
Application:
IHC-P, ICC, IF, WB
Reactivity:
Human, Mouse
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
SDHB (Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial) is an iron-sulfur protein subunit of complex II, having an intermediate role in the electron transfer from the citric acid cycle to the respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. In immunohistochemistry of normal tissue, SDHB has cytoplasmic positivity in all cell types in tissues throughout the body. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804; J. Clin. Endocrinol. Metab. 91 (11): 4505–9, PMID: 16912137;
Target
Human SDHB
Synonyms
SDHB | SDH1 | SDHIP | SDH | IP | PGL4 | SDH2
Host
Rabbit
Reactivity
Human, Mouse (tested or 100% immunogen sequence identity)
Predicted
Rat, Bovine (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with Biotin, DY650, DY488, DY550.
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
A genomic peptide made to an N-Terminus of the human SDHB protein (within residues 1-150). [Swiss-Prot P21912]. Percent identity by BLAST analysis: Rat, Bovine, Porcine (92%); Xenopus (85%); Zebrafish (84%).
Epitope
aa1-150
Applications
  • IHC - Paraffin (1:100)
  • ICC (1:50 - 1:100)
  • Immunofluorescence (1:50 - 1:100)
  • Western blot (1:7000)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Presentation
PBS, 0.05% Sodium Azide, 30% Glycerol
Storage
Short term: store at 4°C. Long term: aliquot and store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About SDHB
P21912 NM_003000 NP_002991.2

Validation

SDHB Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)

SDHB Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

SDHB Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)

LSBio Ratings

PathPlus™ SDHB Antibody (aa1-150) for IHC, ICC, IF/Immunofluorescence, WB/Western LS-B6428 has an LSBio Rating of
Publications (4)
Laboratory Validation Score (5)

Publications (1)

Rare and private variations in neural crest, apoptosis and sarcomere genes define the polygenic background of isolated Tetralogy of Fallot. Grunert M, Dorn C, Schueler M, Dunkel I, Schlesinger J, Mebus S, Alexi-Meskishvili V, Perrot A, Wassilew K, Timmermann B, Hetzer R, Berger F, Sperling SR. Human molecular genetics. 2014 Jun;23:3115-28.

Customer Reviews (0)


Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 11/22/2024