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6737 Mowry Ave
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Customer Service: (800) 227-6666 / (650) 697-3600
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| Catalog Number | Size | Price |
|---|---|---|
| LS-B9360-0.05 | 0.05 mg (0.1 mg/ml) | $460 |
PathPlus™ Monoclonal Mouse anti‑Human SDC1 / Syndecan 1 / CD138 Antibody (clone B‑A38, IHC, IF, WB) LS‑B9360
PathPlus™ Monoclonal Mouse anti‑Human SDC1 / Syndecan 1 / CD138 Antibody (clone B‑A38, IHC, IF, WB) LS‑B9360
Note: This antibody replaces LS-C44877, LS-C44879, LS-C44875
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Specifications
Description
Syndecan 1 (SDC1, CD138) is a cell surface heparin sulfate proteoglycan that links the cytoskeleton to the interstitial matrix. It mediates cell binding, cell signaling, cytoskeletal organization, and participates in cell proliferation and cell migration. It is also involved in internalization of the HIV-1 tat protein. Altered SDC1 expression has been detected in several cancers, including multiple myeloma. It is expressed in plasma cells, squamous epithelia of the esophagus and skin, placental trophoblasts, and a variety of epithelial cells including those of the prostate, GI tract and breast.
References: Ref: Am J Clin Path 2004, 121(2):254; Adv Exp Med Biol 1992, 313:69
Target
Human SDC1 / Syndecan 1 / CD138
Synonyms
SDC1 | CD138 antigen | SDC | SYND1 | Syndecan | Syndecan 1 | Syndecan-1 | CD138 | Syndecan proteoglycan 1
Host
Mouse
Reactivity
Human
(tested or 100% immunogen sequence identity)
Clonality
IgG1
Monoclonal
Clone
B-A38
Purification
Protein G purified
Modifications
Unmodified
Immunogen
U266 cell line
Specificity
Recognizes a heparan sulfate rich membrane glycoprotein of 200kD known as Syndecan-1 (CD138). Syndecan functions as a receptor for collagen, fibronectin and thrombospondin. Stains all plasma cells and plasma cell lines. No staining of other leucocytes is seen in peripheral blood or bone marrow, although some ALL cell lines express the antigen weakly. Some staining of epithelial and endothelial cells may be seen in immunohistology.
Applications
- IHC
- IHC - Paraffin (1:100 - 1:500) & (10 µg/ml)
- IHC - Frozen (1:100 - 1:500)
- Immunofluorescence
- Western blot
- Flow Cytometry (1:1)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
Flow Cytometry: Use 10 ul of the suggested working dilution to label 10^6 cells in 100 ul. Immunohistology: This product requires heat pre-treatment. Sodium citrate buffer pH6.0 is recommended for this purpose.
Presentation
PBS, 0.09% Sodium Azide, 1% BSA
Storage
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
Restrictions
For research use only. Intended for use by laboratory professionals.
About SDC1 / Syndecan 1 / CD138
Validation
Anti-SDC1 / Syndecan 1 / CD138 antibody IHC staining of human tonsil, squamous epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-SDC1 / Syndecan 1 / CD138 antibody IHC staining of human tonsil, squamous epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. This image was taken for the unconjugated form of this product. Other forms have not been tested.
See More About...
LSBio Ratings
PathPlus™ SDC1 / Syndecan 1 / CD138 Antibody (clone B-A38) for IHC, IF/Immunofluorescence, WB/Western, Flow LS-B9360 has an LSBio Rating of
Publications (4.1)
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (2)
Halting the vicious cycle within the multiple myeloma ecosystem: blocking JAM-A on bone marrow endothelial cells restores the angiogenic homeostasis and suppresses tumor progression. Antonio G Solimando, Matteo C Da Vià, Patrizia Leone, Paola Borrelli, Giorgio A Croci, Paula Tabares, Andreas Brandl, Giuseppe Di Lernia, Francesco P Bianchi, Silvio Tafuri, Torsten Steinbrunn, Alessandra Balduini, Assunta Melaccio, Simona De Summa, Antonella Argentiero, Hilka Rauert-Wunderlich, Maria A Frassanito, Paolo Ditonno, Erik Henke, Wolfram Klapper, Roberto Ria, Carolina Terragna, Leo Rasche, Andreas Rosenwald, Martin K Kortüm, Michele Cavo, Domenico Ribatti, Vito Racanelli, Hermann Ein. Haematologica. 2020 April;
Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma. Zongwei Li, Huan Liu, Jin He, Zhiqiang Wang, Zheng Yin, Gichun You, Zhiming Wang, Richard E Davis, Pei Lin, P Leif Bergsagel, Elisabet E Manasanch, Stephen T C Wong, Nestor F Esnaola, Jenny C Chang, Robert Z Orlowski, Qing Yi, Jing Yang. The Breast : official journal of the European Society of Mastology. 2021 January;33:78-93e7.
Customer Reviews (0)
Featured Products
Species:
Human
Applications:
IHC - Paraffin, ELISA
Species:
Human, Mouse
Applications:
IHC, IHC - Paraffin, Western blot
Species:
Human
Applications:
Western blot, ELISA
Species:
Human
Applications:
IHC, Flow Cytometry, ELISA
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 11/22/2024
Date Requested: 11/22/2024
