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| Catalog Number | Size | Price |
|---|---|---|
| LS-B16109-100 | 100 µg (0.5 mg/ml) | $485 |
1 of 2
2 of 2
PathPlus™ Polyclonal Goat anti‑Human POU2F2 / OCT2 Antibody (IHC, WB) LS‑B16109
PathPlus™ Polyclonal Goat anti‑Human POU2F2 / OCT2 Antibody (IHC, WB) LS‑B16109
Note: This antibody replaces LS-C186582
Antibody:
POU2F2 / OCT2 Goat anti-Human Polyclonal Antibody
Application:
IHC-P, WB, Peptide-ELISA
Reactivity:
Human, Mouse
Format:
Unconjugated, Unmodified
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Antibody:
POU2F2 / OCT2 Goat anti-Human Polyclonal Antibody
Application:
IHC-P, WB, Peptide-ELISA
Reactivity:
Human, Mouse
Format:
Unconjugated, Unmodified
Specifications
Description
OCT2 (POU2F2) is a transcription factor that binds the octamer sequence “ATTTGCAT,” a common recognition sequence in immunoglobulin promoter regions. OCT2 plays a role in B-cell differentiation and is a reliable marker for determining B cell lineage. OCT2 can be used in concert with BOB1 to differentiate nodular lymphocyte-predominant Hodgkin lymphoma, which expresses both, from classical Hodgkin lymphoma, which is negative for at least one of the two markers. In immunohistochemistry of normal tissue, OCT2 has nuclear and cytoplasmic localization in immune cells in secondary lymphoid tissues and bone marrow, with high expression in germinal center B cells.
References: Histopathology. 2016 Nov;69(5):775-783, PMID: 27319306; Nucleic Acids Res. 2012 Jan;40 (Database issue):D130-5, PMID: 22121212; Archives of Pathology & Laboratory Medicine. 2008 132:3, 441-461, PMID: 18318586; Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):E2039-46, PMID: 26993806
Target
Human POU2F2 / OCT2
Synonyms
POU2F2 | Homeobox protein | Oct-2 | OCT2 | Octamer-binding protein 2 | OTF-2 | OTF2 | POU class 2 homeobox 2 | Octamer-binding Transcription Factor 2 | POU domain, class 2, transcription factor 2
Host
Goat
Reactivity
Human, Mouse
(tested or 100% immunogen sequence identity)
Predicted
Rat, Dog, Pig (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Modifications
Unmodified
Immunogen
Peptide derived from the N-Terminus of POU2F2 / Oct-2.
Specificity
Human POU2F2 / OCT2
Applications
- IHC - Paraffin (5 µg/ml)
- Western blot (0.1 - 0.3 µg/ml)
- Peptide Enzyme-Linked Immunosorbent Assay (1:128000)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
Peptide ELISA: antibody detection limit dilution 1:128000. Western blot: Approx 60kD band observed in Human Tonsil and Mouse Thymus lysates (calculated MW of 49.5kD according to NP_002689.1). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Pelis et al, Am J Physiol Renal Physiol. 2006 May;290(5): F1118-26. PMID: 16368738). Recommended concentration: 0.1-0.3 ug/ml.
Presentation
TBS, pH 7.3, 0.02% Sodium Azide, 0.5% BSA
Storage
Aliquot and store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About POU2F2 / OCT2
Validation
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
See More About...
LSBio Ratings
PathPlus™ POU2F2 / OCT2 Antibody for IHC, WB/Western LS-B16109 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human, Monkey, Mouse
Applications:
IHC, Immunofluorescence, Western blot, ELISA
Species:
Human
Applications:
IHC, IHC - Paraffin, IHC - Frozen
Species:
Human, Mouse, Rat, Dog, Pig
Applications:
IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot
Species:
Human
Applications:
IHC - Paraffin
Source:
E. coli
Tag:
His-T7
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 12/22/2024
Date Requested: 12/22/2024
