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| Catalog Number | Size | Price |
|---|---|---|
| LS-A463-50 | 50 µg (1 mg/ml) | $460 |
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PathPlus™ Polyclonal Rabbit anti‑Human NPFF2 / NPFFR2 Antibody (N‑Terminus, IHC) LS‑A463
PathPlus™ Polyclonal Rabbit anti‑Human NPFF2 / NPFFR2 Antibody (N‑Terminus, IHC) LS‑A463
Antibody:
NPFF2 / NPFFR2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Overview
Antibody:
NPFF2 / NPFFR2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Specifications
Description
Neuropeptide FF 2 Receptor (NPFF2) is a a GPCR with high affinity for NPAF and NPFF, and which is also weakly activated by FMRF-amide (Phe-Met-Arg-Phe-amide) and a variety of related peptides. NPFF2 is expressed in brain regions associated with opiate activity, consistent with the pain-modulating activity of these peptides, and in adipose tissue, suggesting other physiological and pathophysiological activities for FMRF-amide neuropeptides (Elshourbagy et al, 2000). Four isoforms are produced by alternative splicing.
References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human NPFF2 / NPFFR2
Synonyms
NPFFR2 | G protein-coupled receptor 74 | HLWAR77 | G-protein coupled receptor 74 | Neuropeptide FF receptor 2 | Neuropeptide FF 2 | NPFF2 | Neuropeptide FF 2 receptor | NPGPR | GPR74 | NPFF-R2 | NPFF2 receptor | NPGP receptor
Host
Rabbit
Reactivity
Human
(tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 20 amino acid peptide from N-Terminus extracellular domain of human NPFFR2. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Gibbon (95%).
Epitope
N-Terminus
Specificity
Human NPFFR2. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except MFN2 (45%), MFN1 (45%).
Applications
- IHC
- IHC - Paraffin (1 - 2 µg/ml)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About NPFF2 / NPFFR2
Validation
Brain, Alzheimer's disease, neurofibrillary tangle
Brain, Alzheimer's disease, neurofibrillary tangle
Brain, Cortex, Neurons and glia
Brain, Cortex, Neurons and glia
Brain , Medulla
Brain , Medulla
See More About...
LSBio Ratings
PathPlus™ NPFF2 / NPFFR2 Antibody (N-Terminus) for IHC LS-A463 has an LSBio Rating of
Publications (4)
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (1)
Multiple primary cilia modulate the fluid transcytosis in choroid plexus epithelium. Narita K, Kawate T, Kakinuma N, Takeda S. Traffic (Copenhagen, Denmark). 2010 Feb;11:287-301.
Customer Reviews (0)
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Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 11/22/2024
Date Requested: 11/22/2024
