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Catalog Number Size Price
LS-B10192-100 100 µl $460 
NOS2 / iNOS Antibody - Anti-NOS2 / iNOS antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

PathPlus™ Polyclonal Rabbit anti‑Human NOS2 / iNOS Antibody (clone K13‑A, IHC) LS‑B10192

PathPlus™ Polyclonal Rabbit anti‑Human NOS2 / iNOS Antibody (clone K13‑A, IHC) LS‑B10192

Note: This antibody replaces LS-C149053
Antibody:
NOS2 / iNOS Rabbit anti-Human Polyclonal (K13-A) Antibody
Application:
IHC, IHC-P, IHC-Fr
Reactivity:
Human
Format:
Unconjugated, Unmodified
Price
Catalog Number
$460
LS-B10192-100
Toll Free North America
(800) 227-6666
For Research Use Only

Overview

Antibody:
NOS2 / iNOS Rabbit anti-Human Polyclonal (K13-A) Antibody
Application:
IHC, IHC-P, IHC-Fr
Reactivity:
Human
Format:
Unconjugated, Unmodified

Specifications

Description
NOS2 (iNOS, nitric oxide synthase 2, inducible) is a synthase for nitric oxide, a reactive free radical and messenger molecule that acts a biologic mediator in neurotransmission and antimicrobial/anti-cancer processes. In macrophages, nitric oxide mediates tumoricidal and bactericidal actions. It also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2. In immunohistochemistry, NOS2 antibodies may be used to characterize epithelial injury and cells undergoing apoptosis in sites of inflammation. NOS2 may be useful in diagnosing liver diseases, as NOS2 has high expression in a number of pathologies and is involved in the etiology of liver fibrosis. Furthermore, antibodies to NOS2 may have utility in cancer: elevated levels of NOS2 have been found in cancers of the lung, colon, and prostate as well as in melanoma, glioblastoma and oral dysplasia, and high levels of NOS2 in cancers are generally correlated with poor prognosis. In normal tissue, NOS2 is positive in the gastrointestinal tract, appendix and urinary bladder. References: Proc Natl Acad Sci USA. 90 (8): 3491–5, PMID: 7682706; Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000 Nov; 90(5):624-9, PMID: 11077387; Clin Cancer Res. 2000 Dec; 6(12):4768-75, PMID: 11156233; Med Oral Patol Oral Cir Bucal. 2014 May; 19(3): e242–e247, PMID: 24316703; Arch Pathol Lab Med. 2009 Jan;133(1):97-100, PMID: 19123745; Clin Mol Hepatol. 2015 Dec; 21(4): 319–325, PMID: 26770919;
Target
Human NOS2 / iNOS
Synonyms
NOS2 | Hepatocyte NOS | HEP-NOS | Inducible NOS | NOS, type II | NOS type II | Inducible NO synthase | NOS2A | INOS | NOS
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Clone
K13-A
Conjugations
Unconjugated
Modifications
Unmodified
Immunogen
Peptide derived from human iNOS sequence
Applications
  • IHC
  • IHC - Paraffin (1:200)
  • IHC - Frozen
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Presentation
20 mM Tris-HCl, pH 8.0, 20 mg/ml BSA stabilzer, 0.05% NaN3 preservative
Storage
Store at 4°C. Avoid freezing.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About NOS2 / iNOS
P35228 NM_000625 NP_000616.3

Validation

NOS2 / iNOS Antibody - Anti-NOS2 / iNOS antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-NOS2 / iNOS antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-NOS2 / iNOS antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

LSBio Ratings

PathPlus™ NOS2 / iNOS Antibody (clone K13-A) for IHC LS-B10192 has an LSBio Rating of
Laboratory Validation Score (5)

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Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 12/22/2024