MOG (Myelin oligodendrocyte glycoprotein) is a membrane protein found on the cell surface of oligodendrocyte and the outermost surface of myelin sheaths. It functions in the myelination of nerves in the central nervous system, and is involved in maintaining myelin sheath structural integrity and in cellular communication. Some individuals with multiple sclerosis and neuromyelitis optica spectrum disorders (NMOSD) produce autoantibodies to MOG, which may contribute to flares of inflammatory demyelination in the central nervous system. In immunohistochemistry, MOG is only found in the central nervous system, and has membranous positivity on oligodendrocytes. References: Neurology. Neuroimmunology and Neuroinflammation. 2016. 3(5), DOI: 10.1212/NXI.0000000000000257; Ther Adv Neurol Disord. 2018; 11, PMID: 29623106