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| Catalog Number | Size | Price |
|---|---|---|
| LS-A135-50 | 50 µg (1 mg/ml) | $460 |
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2 of 4
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PathPlus™ Polyclonal Rabbit anti‑Human MLNR/GPR38/Motilin Receptor Antibody (Cytoplasmic Domain, IHC) LS‑A135
PathPlus™ Polyclonal Rabbit anti‑Human MLNR/GPR38/Motilin Receptor Antibody (Cytoplasmic Domain, IHC) LS‑A135
Antibody:
MLNR/GPR38/Motilin Receptor Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Overview
Antibody:
MLNR/GPR38/Motilin Receptor Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Specifications
Description
MLNR (GPR38, Motilin Receptor) is a G protein-coupled receptor that mediates smooth muscle contraction and controls gastrointestinal motility by binding motilin. The antibiotic erythromycin-A also induces smooth muscle contraction when binding to the motilin receptor. Associations exist between the motilin peptide and several gastrointestinal diseases, such as Crohn's disease, inflammatory bowel disease, and ulcerative colitis. The motilin receptor may also be implicated in the progression of these diseases. It is a target of numerous agonists in development for the potential acceleration of gastric emptying or for other therapeutic purposes. In immunohistochemistry, MLNR has membranous positivity in the gastrointestinal tract, brain, thyroid and bone marrow.
References: Br J Pharmacol. 2013 Dec; 170(7): 1323–1332, PMID: 23189978
Target
Human MLNR/GPR38/Motilin Receptor
Synonyms
MLNR | G-protein coupled receptor 38 | Motilin receptor | MTLR | MTLR1 | G protein-coupled receptor 38 | GPR38
Host
Rabbit
Reactivity
Human
(tested or 100% immunogen sequence identity)
Predicted
Monkey, Bat (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 20 amino acid peptide from 3rd cytoplasmic domain of human MLNR. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Monkey (95%); Gibbon, Marmoset, Bat (90%); Dog, Panda (85%); Bovine (80%).
Epitope
Cytoplasmic Domain
Specificity
Human MLNR. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
- IHC
- IHC - Paraffin (1.1 µg/ml)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About MLNR/GPR38/Motilin Receptor
Validation
Skin, Malignant Melanoma
Skin, Malignant Melanoma
Brain, Glioblastoma
Brain, Glioblastoma
Anti-MLNR antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-MLNR antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Breast, Carcinoma
Breast, Carcinoma
See More About...
LSBio Ratings
PathPlus™ MLNR/GPR38/Motilin Receptor Antibody (Cytoplasmic Domain) for IHC LS-A135 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human, Monkey
Applications:
IHC, IHC - Paraffin
Species:
Human
Applications:
Western blot, ELISA
Species:
Human
Applications:
IHC, IHC - Paraffin
Species:
Human, Monkey
Applications:
IHC, IHC - Paraffin
Species:
Human
Applications:
Western blot, ELISA
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 12/29/2024
Date Requested: 12/29/2024
