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| Catalog Number | Size | Price |
|---|---|---|
| LS-B8321-50 | 50 µg (0.5 mg/ml) | $485 |
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PathPlus™ Polyclonal Goat anti‑Human LSP1 Antibody (aa445‑459, IHC, WB) LS‑B8321
PathPlus™ Polyclonal Goat anti‑Human LSP1 Antibody (aa445‑459, IHC, WB) LS‑B8321
Note: This antibody replaces LS-C112940
Antibody:
LSP1 Goat anti-Human Polyclonal (aa445-459) Antibody
Application:
IHC-P, WB, Peptide-ELISA
Reactivity:
Human, Monkey, Mouse, Rat, Dog, Hamster
Format:
Unconjugated, Unmodified
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Antibody:
LSP1 Goat anti-Human Polyclonal (aa445-459) Antibody
Application:
IHC-P, WB, Peptide-ELISA
Reactivity:
Human, Monkey, Mouse, Rat, Dog, Hamster
Format:
Unconjugated, Unmodified
Specifications
Description
LSP1 is an intracellular F-actin binding protein expressed in lymphocytes, neutrophils, macrophages, and endothelium. It regulates neutrophil motility, adhesion to fibrinogen matrix proteins, transendothelial migration, and actomyosin contractility in macrophages. Some inherited polymorphisms in LSP1 are associated with increased risk for breast cancer. In immunohistochemistry, LSP1 has membranous and cytoplasmic positivity in immune cells.
References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804; Int J Clin Exp Pathol. 2015; 8(5): 5798–5802, PMID: 26191300; Nat Commun 9, 515 (2018), DOI:10.1038/s41467-018-02904-x
Target
Human LSP1
Synonyms
LSP1 | 47 kDa actin-binding protein | 47 kDa actin binding protein | 52 kDa phosphoprotein | Leukocyte-specific protein 1 | Lymphocyte-specific protein 1 | Pp52 | WP34
Host
Goat
Reactivity
Human, Monkey, Mouse, Rat, Dog, Hamster
(tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Modifications
Unmodified
Immunogen
Peptide with sequence C-RYKFVATGHGKYEKV, from the C-Terminus of protein sequence according to NP_002330.1NP_001013271.1.
Epitope
aa445-459
Specificity
Human LSP1. This antibody is expected to recognize both reported isoforms (NP_002330.1; NP_001013271.1). Reported variants represent identical protein: NP_001013273.1, NP_001013271.1, NP_001013272.1
Applications
- IHC - Paraffin (3.75 µg/ml)
- Western blot (0.05 - 0.2 µg/ml)
- Peptide Enzyme-Linked Immunosorbent Assay (1:16000)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
Peptide ELISA: antibody detection limit dilution 1:16000. Western blot: Approx 50kDa band observed in Human Lymph Node, Tonsil and Peripheral Blood Mononucleocytes lysates (calculated MW of 37.2kDa according to NP_002330.1). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Liu et al, J Exp Med. 2005 Feb 7;201(3):409-18; PMID: 15684321) . Recommended concentration: 0.05-0.2 ug/ml.
Presentation
TBS, pH 7.3, 0.02% Sodium Azide, 0.5% BSA
Storage
Aliquot and store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About LSP1
Validation
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)
See More About...
LSBio Ratings
PathPlus™ LSP1 Antibody (aa445-459) for IHC, WB/Western LS-B8321 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human, Mouse, Rat
Applications:
IHC - Paraffin, Western blot
Species:
Human, Mouse, Rat
Applications:
IHC - Paraffin, Western blot
Species:
Human, Mouse, Rat
Applications:
IHC - Paraffin, Western blot
Species:
Human, Mouse, Rat
Applications:
IHC - Paraffin, Western blot
Species:
Human
Applications:
IHC, IHC - Paraffin, Western blot, Flow Cytometry
Source:
E. coli
Tag:
His-GST
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 11/22/2024
Date Requested: 11/22/2024
