LPAR3 (EDG7) is a G protein-coupled receptorreceptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. It is coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins. It may play a role in the development of ovarian cancer. In immunohistochemistry, LPAR3 has membranous expression on populations of cells throughout the central nervous system - it has the strongest staining in the amygdala, hippocampus, cortex, putamen, and thalamus. In peripheral tissues it is positive on epithelial cells in tubular, solid and endocrine organs and on ganglion cells throughout all organs. It has focal staining in skeletal muscle and is also found on mast cells and macrophages. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804