LPAR2 is a receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. It is coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. It plays an important role in the phospholipase C-beta (PLC-beta) signaling pathway, and it stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation. LPAR2 is important for vascular development, and loss of this protein results can result in vascular defects including frontal cerebral hematomas. Furthermore, loss of LPAR2 signaling in multiple sclerosis and experimental autoimmune encephalomyelitis (in mice) promotes disease progression. In immunohistochemistry, LPAR2 has membranous and cytoplasmic positivity in most tissues throughout the body. References: Neuron. 2015 Feb 18;85(4):669-82, PMID: 25695267; Acta Neuropathol Commun. 2017 Jun 2;5(1):42, PMID: 28578681