LHCGR (Luteinizing hormone/choriogonadotropin receptor)is a receptor for both luteinizing hormone and choriogonadotropin. It is expressed in the reproductive organs of both males and females. In males, LHCGR is involved in the development and function of Leydig cells. Mutations in this gonadotropin receptor can result in disorders of male secondary sexual character development, such as familial male precocious puperty and male pseudohermaphroditism, or lead to adenomas of the testis. In females, inactivating mutations of LHCGR cause hypergonadotrophic hypogonadism with primary amenorrhea or oligomenorrhea, cystic ovaries, and infertility. LHCGR has many alternatively spliced isoforms that affect where this gene is expressed. References: Human Reproduction Update, Volume 19, Issue 5, September/October 2013, Pages 583–602; Front. Endocrinol., 29 September 2015, DOI:10.3389/fendo.2015.00152;