LAMC1 (Laminin subunut gamma-1, LAMB2) is an extracellular matrix glycoprotein that is a major component of basement membranes. The LAMC1 subunit is essential for proper laminin heterotrimer assembly during embryogenesis, and absence of this subunit is lethal. Mutations in LAMC1 lead to Dandy-Walker malformation and occipital cephaloceles, described by defects in the occipital skull, meningeal anomalies and cerebellar hypoplasia. In gliomas, high expression of LAMC1 is correlated with high grade status and a poorer prognosis. In immunohistochemistry, LAMC1 has secretory and extracellular positivity in smooth muscle and basement membranes. References: Nucleic Acids Res. 2002 Jun 1; 30(11): 2270–2279, PMID: 12034813; Hum Mutat. 2013 Aug;34(8):1075-9, PMID: 23674478; Onco Targets Ther. 2019 May 29;12:4253-4260, PMID: 31213842;