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| Catalog Number | Size | Price |
|---|---|---|
| LS-B16820-50 | 50 µl (1 mg/ml) | $460 |
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PathPlus™ Polyclonal Rabbit anti‑Human KRT8 / CK8 / Cytokeratin 8 Antibody (C‑Terminus, IHC, IF, WB) LS‑B16820
PathPlus™ Polyclonal Rabbit anti‑Human KRT8 / CK8 / Cytokeratin 8 Antibody (C‑Terminus, IHC, IF, WB) LS‑B16820
Note: This antibody replaces LS-C368397
Antibody:
KRT8 / CK8 / Cytokeratin 8 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Application:
IHC-P, ICC, IF, WB
Reactivity:
Human, Mouse
Format:
Unconjugated, Unmodified
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Antibody:
KRT8 / CK8 / Cytokeratin 8 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Application:
IHC-P, ICC, IF, WB
Reactivity:
Human, Mouse
Format:
Unconjugated, Unmodified
Specifications
Description
Cytokeratin 8 (KRT8, CK8) is a Type II intermediate filament chain keratin that is expressed in simple glandular epithelia and the liver. Along with KRT18, KRT8 protects the liver from stress-induced injury and apoptosis. Mutations in this gene have been linked to cryptogenic cirrhosis, rhabdoid tumors, chronic pancreatitis and liver disease. It is a component of nuclear inclusions in rhaboid tumors and Mallory bodies in liver diseases. KRT8 is positive in a variety of cancers.
References: Hepatology 2007 46(5):1639; Mod Pathol 2002 15:146; Dig Liver dis 2003 35:416; J Cell Biol 2005 171(6):931
Target
Human KRT8 / CK8 / Cytokeratin 8
Synonyms
KRT8 | CARD2 | CK-8 | CYK8 | Cytokeratin-8 | CK8 | K2C8 | K8 | KO | Keratin-8 | Type-II keratin Kb8 | Cytokeratin 8 | Keratin 8
Host
Rabbit
Reactivity
Human, Mouse
(tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the C-Terminus of human Cytokeratin 8.
Epitope
C-Terminus
Specificity
Recognizes endogenous levels of Cytokeratin 8 (pS432) protein.
Applications
- IHC - Paraffin (1:100)
- ICC (1:100 - 1:500)
- Immunofluorescence
- Western blot (1:500 - 1:1000)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, pH 7.3, 0.01% Sodium Azide, 30% Glycerol
Storage
Aliquot and store at -20°C for 1 year. Avoid freeze/thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About KRT8 / CK8 / Cytokeratin 8
Validation
Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
See More About...
LSBio Ratings
PathPlus™ KRT8 / CK8 / Cytokeratin 8 Antibody (C-Terminus) for IHC, ICC, IF/Immunofluorescence, WB/Western LS-B16820 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human, Bovine, Rabbit, Sheep, Porcine
Applications:
IHC, IHC - Paraffin, ICC, Western blot, Immunoprecipitation
Species:
Human
Applications:
IHC, IHC - Paraffin, IHC - Frozen, ICC, Western blot, Flow Cytometry
Species:
Human
Applications:
IHC, IHC - Paraffin, IHC - Frozen, ICC, Western blot, Flow Cytometry
Species:
Human
Applications:
IHC, IHC - Paraffin, Western blot
Species:
Human, Monkey, Dog
Applications:
IHC, IHC - Paraffin, Immunofluorescence, Western blot
Species:
Human, Mouse, Rat, Bovine, Dog, Pig, Rabbit
Applications:
IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 11/22/2024
Date Requested: 11/22/2024
