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| Catalog Number | Size | Price |
|---|---|---|
| LS-B16654-100 | 100 µg | $460 |
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PathPlus™ Polyclonal Rabbit anti‑Human KRT8 / CK8 / Cytokeratin 8 Antibody (aa2‑483, IHC, WB) LS‑B16654
PathPlus™ Polyclonal Rabbit anti‑Human KRT8 / CK8 / Cytokeratin 8 Antibody (aa2‑483, IHC, WB) LS‑B16654
Note: This antibody replaces LS-C370741
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Specifications
Description
Cytokeratin 8 (KRT8, CK8) is a Type II intermediate filament chain keratin that is expressed in simple glandular epithelia and the liver. Along with KRT18, KRT8 protects the liver from stress-induced injury and apoptosis. Mutations in this gene have been linked to cryptogenic cirrhosis, rhabdoid tumors, chronic pancreatitis and liver disease. It is a component of nuclear inclusions in rhaboid tumors and Mallory bodies in liver diseases. KRT8 is positive in a variety of cancers.
References: Hepatology 2007 46(5):1639; Mod Pathol 2002 15:146; Dig Liver dis 2003 35:416; J Cell Biol 2005 171(6):931
Target
Human KRT8 / CK8 / Cytokeratin 8
Synonyms
KRT8 | CARD2 | CK-8 | CYK8 | Cytokeratin-8 | CK8 | K2C8 | K8 | KO | Keratin-8 | Type-II keratin Kb8 | Cytokeratin 8 | Keratin 8
Host
Rabbit
Reactivity
Human
(tested or 100% immunogen sequence identity)
Clonality
IgG
Polyclonal
Purification
Caprylic acid and ammonium sulfate precipitation
Modifications
Unmodified
Immunogen
Recombinant human Keratin, type II cytoskeletal 8 protein (aa2-483).
Epitope
aa2-483
Specificity
Human KRT8 / CK8 / Cytokeratin 8
Applications
- IHC - Paraffin (10 µg/ml)
- Western blot
- ELISA
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Storage
Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About KRT8 / CK8 / Cytokeratin 8
Validation
Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
See More About...
LSBio Ratings
PathPlus™ KRT8 / CK8 / Cytokeratin 8 Antibody (aa2-483) for IHC, WB/Western, ELISA LS-B16654 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
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Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 11/3/2024
Date Requested: 11/3/2024
