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| Catalog Number | Size | Price |
|---|---|---|
| LS-B16250-100 | 100 µg (200 µg/ml) | $525 |
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PathPlus™ Recombinant Monoclonal Mouse anti‑Human KRT16 / CK16 / Cytokeratin 16 Antibody (clone KRT16/1714, C‑Terminus, IHC) LS‑B16250
PathPlus™ Recombinant Monoclonal Mouse anti‑Human KRT16 / CK16 / Cytokeratin 16 Antibody (clone KRT16/1714, C‑Terminus, IHC) LS‑B16250
Note: This antibody replaces LS-C751232
Antibody:
KRT16 / CK16 / Cytokeratin 16 Mouse anti-Human Recombinant Monoclonal (C-Terminus) (KRT16/1714) Antibody
Application:
IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Antibody:
KRT16 / CK16 / Cytokeratin 16 Mouse anti-Human Recombinant Monoclonal (C-Terminus) (KRT16/1714) Antibody
Application:
IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Specifications
Description
KRT16 (Cytokeratin 16, CK16) is a type I cytokeratin that partners with Keratin 6A to form keratin intermediate filaments. KRT16 is found in non-keratinizing squamous epithelium of the esophagus, tongue, oral cavity, tonsil, ectocervix, vagina, and in melanocytes, hair follicles and nails. Increased expression is found in conditions involving hyperplastic keratinocytes, including psoriasis, and decreased expression is observed in cervical carcinoma. Mutations are associated with pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus syndromes.
References: J Anat 2009 214(4):516; Am J Dermatopath 2005 27(6):476; Exp Dermatol 2013 22(12):838; Human Mol Genet 2019:doi.org/10.1093/ddz050
Target
Human KRT16 / CK16 / Cytokeratin 16
Synonyms
KRT16 | CK16 | Cytokeratin 16 | Cytokeratin-16 | FNEPPK | K1CP | Keratin-16 | Keratin 16 | NEPPK | CK-16 | K16 | KRT16A
Host
Mouse
Reactivity
Human
(tested or 100% immunogen sequence identity)
Clonality
IgG1
Recombinant Monoclonal
Clone
KRT16/1714
Conjugations
Unconjugated
Purification
Protein A/G purified
Modifications
Unmodified.
Also available Azide-free, Carrier-free.
Immunogen
Recombinant fragment from the C-Terminus of human Cytokeratin 16. Antigen Molecular Weight: 48 kDa
Epitope
C-Terminus
Specificity
Cytokeratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I Cytokeratins (Cytokeratins 9 to 23) and one type II Cytokeratins (keratins 1 to 8). The cytokeratin proteins play a critical role in differentiation, as well as tissue specialization and function, to maintain the overall structural integrity of epithelial cells. Cytokeratins are also useful markers in identifying the origin of metastatic tumors. Cytokeratin 16 is expressed in benign stratified squamous epithelium and squamous cell carcinoma of the head and neck, as well as luminal cells of mammary gland and sweat ducts. It is absent in non-invasive breast carcinomas and normal breast tissue.
Applications
- IHC - Paraffin (1:50)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
Immunohistology (Frozen & Formalin-fixed - 0.5-1 ug/ml for 30 min at RT - Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.) Optimal dilution for a specific application should be determined.
Presentation
10 mM PBS, 0.05% BSA, 0.05% Sodium Azide
Storage
Store at 2°C to 8°C for up to 2 years.
Restrictions
For research use only. Intended for use by laboratory professionals.
About KRT16 / CK16 / Cytokeratin 16
Validation
Human Hair Follicle: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Hair Follicle: Formalin-Fixed, Paraffin-Embedded (FFPE)
See More About...
LSBio Ratings
PathPlus™ KRT16 / CK16 / Cytokeratin 16 Antibody (C-Terminus, clone KRT16/1714) for IHC LS-B16250 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human
Applications:
IHC, IHC - Paraffin, IHC - Frozen
Species:
Human
Applications:
IHC - Paraffin
Species:
Human
Applications:
IHC, IHC - Paraffin, IHC - Frozen
Species:
Human
Applications:
IHC, IHC - Paraffin, Western blot
Species:
Human, Mouse, Rat
Applications:
IHC, IHC - Paraffin, Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Species:
Human
Applications:
IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 12/19/2024
Date Requested: 12/19/2024
