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| Catalog Number | Size | Price |
|---|---|---|
| LS-B15876-50 | 50 µl (1 mg/ml) | $460 |
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PathPlus™ Polyclonal Rabbit anti‑Human KCNJ2 / Kir2.1 Antibody (Internal, IHC, WB) LS‑B15876
PathPlus™ Polyclonal Rabbit anti‑Human KCNJ2 / Kir2.1 Antibody (Internal, IHC, WB) LS‑B15876
Note: This antibody replaces LS-C358787
Antibody:
KCNJ2 / Kir2.1 Rabbit anti-Human Polyclonal (Internal) Antibody
Application:
IHC-P, WB
Reactivity:
Human, Mouse, Rat
Format:
Unconjugated, Unmodified
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Antibody:
KCNJ2 / Kir2.1 Rabbit anti-Human Polyclonal (Internal) Antibody
Application:
IHC-P, WB
Reactivity:
Human, Mouse, Rat
Format:
Unconjugated, Unmodified
Specifications
Description
KCNJ2 (Kir2.1 inward-rectifier potassium ion channel) is a potassium ion channel protein that maintains resting membrane potential and regulates cell excitability. It plays an important role in neural and craniofacial development. It is highly expressed in the hippocampus, nucleus accumbens, putamen and caudate in the brain as well as in skeletal muscle, and is central to the inward-rectifier current (IK1) that controls cardiac excitability in human ventricular muscle. Mutations in KCNJ2 affect neuronal excitability and are associated with Autism, short-QT syndrome and Andersen-Tawil syndrome. In immunohistochemistry, KCNJ2 has cytoplasmic positivity in most tissues throughout the body.
References: Front. Cell. Neurosci. 2018, DOI: 10.3389/fncel.2018.00076; Heart Rhythm. 2005 Mar;2(3):316-24, PMID: 15851327; Cardiovascular Research. 2012. 93 (4): 666–673, DOI:10.1093/cvr/cvr329; J Physiol. 2016 Jun 15;594(12):3245-70, PMID: 26864374
Target
Human KCNJ2 / Kir2.1
Synonyms
KCNJ2 | ATFB9 | HHBIRK1 | IRK1 | KIR2.1 | LQT7 | HIRK1 | IRK-1 | HHIRK1 | SQT3
Host
Rabbit
Reactivity
Human, Mouse, Rat
(tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the central region of human Kir2.1.
Epitope
Internal
Specificity
Recognizes endogenous levels of Kir2.1 protein.
Applications
- IHC - Paraffin (5 µg/ml)
- Western blot (1:500 - 1:1000)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, pH 7.3, 0.01% Sodium Azide, 30% Glycerol
Storage
Aliquot and store at -20°C for 1 year. Avoid freeze/thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About KCNJ2 / Kir2.1
Validation
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
See More About...
LSBio Ratings
PathPlus™ KCNJ2 / Kir2.1 Antibody (Internal) for IHC, WB/Western LS-B15876 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
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Featured Products
Species:
Mouse, Human, Rat
Applications:
IHC, Western blot
Species:
Human, Mouse
Applications:
IHC, IHC - Paraffin, Western blot, Flow Cytometry
Species:
Mouse, Rat
Applications:
IHC, ICC, Immunofluorescence, Western blot
Species:
Human, Mouse, Rat
Applications:
IHC, Western blot, ELISA
Source:
E. coli
Tag:
His-GST
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 11/3/2024
Date Requested: 11/3/2024
