IL23R forms the interleukin-23 receptor together with IL12RB1. It binds IL23 and is present on subsets of T cells, some B cells and innate lymphoid cells. IL23R functions in innate and adaptive immunity, inflammatory response and acute response to infection in peripheral tissues. Polymorphisms in IL23R are associated with inflammatory bowel disease, psoriasis and ankylosing spondylitis, and some mutations are also correlated with risk for rectal cancer. In immunohistochemistry, IL23R has low levels of positivity on populations of immune cells and in the adrenal gland, gastrointestinal tract and reproductive tissues. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804; Hum Immunol. 2007 Nov;68(11):934-7, PMID: 18082575; Cancer Epidemiol. 2012 Apr;36(2):e104-10, PMID: 22154103; PLoS One. 2014; 9(2): e89092, PMID: 24586521