Products

Research Areas

COVID-19

Resources

Distributors

Quick Order

Cart

Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.

Forgot password?

Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.

Login Name*:
Email*:
Password*:
Confirm Password*:
Name:
Organization:
Role:

Fields marked with a * are required.

Quick Order

Cart

Products

Antibodies

All Antibodies Primary Antibodies Secondary Antibodies IHC-plus™ Antibodies PathPlus™ Antibodies Isotype Control Antibodies

ELISA and Assay Kits

All Kits Assay Kits Traditional ELISA Kits Cell-Based ELISA Kits DNA-Binding ELISA Kits Phospho-Specific ELISA Kits ELISA Development Kits Chemiluminescent CLIA Kits

Proteins

All Proteins Recombinant Proteins Native Proteins Over-Expression Lysates Bio-Active Proteins Animal-Free Proteins Synthetic Peptides Cell and Tissue Lysates

Research Areas

Cancer Research

Breast Cancer IHC Colorectal Cancer IHC Lung Cancer IHC Prostate Cancer IHC

Pathways And Groups

Apoptosis Caspases Chemokines

Infectious Disease

Virology Coronaviridae (COVID-19) Hepatitis Viruses Herpesviridae (Herpes) Orthomyxoviridae (Influenza) Papillomaviridae (HPV) Paramyxoviridae (Mumps) Pneumoviridae (RSV) Polyomaviridae (SV40) Retroviridae (HIV) Togaviridae (Measles)

Neurodegenerative Disease

Alzheimer's Disease

COVID-19

Coronavirus Detection Coronavirus and COVID-19 Inhibitors Coronavirus Antibodies, Proteins, and cDNAs Cytokine Release Syndrome General Coronavirus Information

Resources

Purchasing

Product Ordering Terms and Conditions Holiday Schedule About the LSBio Guarantee About Reviews

Reference Material

About LSBio (LifeSpan BioSciences Inc.) About Our IHC Validation Process About Our IHC-plus™ Immunohistochemistry Protocol About Our Protocols LSBio ELISA Kit Development Guide Media

Secure Logins

How To Buy

Location

Corporate Headquarters

Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States

Telephone Numbers

Customer Service: (800) 227-6666 / (650) 697-3600

Contact Us

Additional Contact Details

Distributors

Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.

Forgot password?

Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.

Login Name*:
Email*:
Password*:
Confirm Password*:
Name:
Organization:
Role:

Fields marked with a * are required.

Quick Order

Catalog Number	Size	Price
LS-A650-50	50 µg (1 mg/ml)	$440

HTR6 / 5-HT6 Receptor Antibody - Brain, Basal Ganglia

HTR6 / 5-HT6 Receptor Antibody - Brain, substantia nigra

HTR6 / 5-HT6 Receptor Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)

HTR6 / 5-HT6 Receptor Antibody - Anti-HTR6 / 5-HT6 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

HTR6 / 5-HT6 Receptor Antibody - Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)

1 of 5

2 of 5

3 of 5

4 of 5

5 of 5

PathPlus™ Polyclonal Rabbit anti‑Human HTR6 / 5‑HT6 Receptor Antibody (C‑Terminus, IHC) LS‑A650

Name: PathPlus™ HTR6 / 5-HT6 Receptor Polyclonal Antibody Rabbit IHC | LSBio
Brand: Lifespan BioSciences
SKU: LS-A650-50
Price: 440.0000 USD
Availability: InStock
Rating: 5 (1 reviews)

Neuroscience

(5.0) Rating

Submit Review LSBio Guarantee

Antibody:

HTR6 / 5-HT6 Receptor Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Application:

IHC, IHC-P

Reactivity:

Human

Format:

Unconjugated, Unmodified

$440

LS-A650-50

Ready To Ship

Toll Free North America

(800) 227-6666

For Research Use Only

Specifications Validation Publications Reviews Featured Products Request SDS/MSDS

Overview

Antibody:

HTR6 / 5-HT6 Receptor Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Application:

IHC, IHC-P

Reactivity:

Human

Format:

Unconjugated, Unmodified

Specifications

Description

5-HT6 receptor (HTR6) is a Serotonin Receptor that regulates cholinergic neurotransmission in the brain rather than the expected interaction as a modulator of dopaminergic transmission. HTR6 predicts a possible role for 5-HT6 Receptor antagonists in the treatment of learning and memory disorders. The 5-HT6 Receptor is abundant in limbic areas, which participate in the control of mood and emotion. Some antidepressants and antipsychotics are potent 5-HT6 Receptor antagonists, making this gene valuable for the pharmaceutical industry. 5-HT6 may be involved in the pathogenesis of mood disorders, schizophrenia, and Alzheimer's disease. A splice variant that has a 289bp deletion in the transmembrane region IV and the third intracellular loop has been isolated. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804

Target

Human HTR6 / 5-HT6 Receptor

Synonyms

See All HTR6 / 5-HT6 Receptor Antibodies

Host

Rabbit

Reactivity

Human (tested or 100% immunogen sequence identity)

Predicted

Monkey, Horse (at least 90% immunogen sequence identity)

Clonality

Polyclonal

Conjugations

Unconjugated

Purification

Immunoaffinity purified

Modifications

Unmodified

Immunogen

Synthetic 17 amino acid peptide from C-Terminus of human HTR6 / 5-HT6. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla (100%); Monkey, Horse (94%); Gibbon, Dog, Rabbit (88%); Elephant (82%).

Epitope

C-Terminus

Specificity

Human HTR6 / 5-HT6. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Applications

IHC
IHC - Paraffin (2.5 - 5 µg/ml)

Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.

Presentation

PBS, 0.1% Sodium Azide

Storage

Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.

Restrictions

For research use only. Intended for use by laboratory professionals.

Guarantee

This antibody carries the LSBio 100% Guarantee.

LSBio Guarantee

About HTR6 / 5-HT6 Receptor

Uniprot: P50406 NCBI: NM_000871 NP_000862.1

Validation

Brain, Basal Ganglia

Brain, substantia nigra

Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-HTR6 / 5-HT6 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.