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| Catalog Number | Size | Price |
|---|---|---|
| LS-B16454-50 | 50 µl (0.99 mg/ml) | $460 |
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PathPlus™ Monoclonal Mouse anti‑Human HES1 / HES‑1 Antibody (clone OTI1B5, IHC, IF, WB) LS‑B16454
PathPlus™ Monoclonal Mouse anti‑Human HES1 / HES‑1 Antibody (clone OTI1B5, IHC, IF, WB) LS‑B16454
Note: This antibody replaces LS-C173601
Antibody:
HES1 / HES-1 Mouse anti-Human Monoclonal (OTI1B5) Antibody
Application:
IHC-P, IF, WB
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Antibody:
HES1 / HES-1 Mouse anti-Human Monoclonal (OTI1B5) Antibody
Application:
IHC-P, IF, WB
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Specifications
Description
HES1 (Hes family bHLH transcription factor 1) is a repressor of genes that require a bHLH protein for their transcription. It acts to negatively regulate myogenesis by inhibiting the functions of MYOD1 and ASH1. HES1 binds DNA on N-box motifs such as 5'-CACNAG-3' with high affinity and on E-box motifs such as 5'-CANNTG-3' with low affinity. It may play a role in a functional FA core complex response to DNA cross-link damage, is required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 mono-ubiquitination in response to DNA damage. It has been implicated in cell differentiation, cell cycle arrest and apoptosis, and metastasis in cancer. It is expressed in the nucleus of a variety of tissues.
References: Cancer Biol Ther. 2015 Mar; 16(3): 353–359
Target
Human HES1 / HES-1
Synonyms
HES1 | BHLHb39 | HHL | HL | Hairy and enhancer of split 1 | Hairy homolog | HRY | Hairy homolog (Drosophila) | Transcription factor HES-1 | Hairy-like protein | HES-1
Host
Mouse
Reactivity
Human
(tested or 100% immunogen sequence identity)
Clonality
IgG2b
Monoclonal
Clone
OTI1B5
Conjugations
Unconjugated
Purification
Protein A/G purified
Modifications
Unmodified.
Also available Carrier-free.
Immunogen
Full length human recombinant protein of human HES1(NP_005515) produced in HEK293T cell.
Specificity
Human HES1
Applications
- IHC - Paraffin (1:50)
- Immunofluorescence (1:100)
- Western blot (1:500 - 1:2000)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, pH 7.3, 0.02% Sodium Azide, 50% Glycerol, 1% BSA
Storage
Store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About HES1 / HES-1
Validation
Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
See More About...
LSBio Ratings
PathPlus™ HES1 / HES-1 Antibody (clone OTI1B5) for IHC, IF/Immunofluorescence, WB/Western LS-B16454 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human, Monkey, Mouse, Rat, Bat, Bovine, Hamster, Horse, Rabbit, Xenopus, Zebrafish
Applications:
IHC, IHC - Paraffin, IHC - Frozen, Immunofluorescence, Western blot
Species:
Human, Mouse, Rat
Applications:
IHC, IHC - Paraffin, Western blot, ELISA
Species:
Human
Applications:
IHC, IHC - Paraffin, Immunofluorescence, Western blot, Flow Cytometry
Species:
Rat, Mouse
Applications:
ICC, Western blot, Immunoprecipitation
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 11/22/2024
Date Requested: 11/22/2024
