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| Catalog Number | Size | Price |
|---|---|---|
| LS-B16318-100 | 100 µg (0.2 mg/ml) | $525 |
PathPlus™ Monoclonal Mouse anti‑Human Hepatocyte Specific Antigen Antibody (clone HepPar1, IHC, IF) LS‑B16318
PathPlus™ Monoclonal Mouse anti‑Human Hepatocyte Specific Antigen Antibody (clone HepPar1, IHC, IF) LS‑B16318
Note: This antibody replaces LS-C391504
Antibody:
Hepatocyte Specific Antigen Mouse anti-Human Monoclonal (HepPar1) Antibody
Application:
IHC, IHC-P, IF
Reactivity:
Human, Dog
Format:
Unconjugated, Unmodified
Other formats:
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Antibody:
Hepatocyte Specific Antigen Mouse anti-Human Monoclonal (HepPar1) Antibody
Application:
IHC, IHC-P, IF
Reactivity:
Human, Dog
Format:
Unconjugated, Unmodified
Other formats:
Specifications
Description
Hepatocyte Specific Antigen (HepPar1, Hep paraffin 1, OCH1E5) is an antigen expressed in hepatocyte mitochondria. In immunohistochemistry, it is considered a sensitive marker for differentiating hepatocellular carcinomas (HCC) from other cancers such as cholangiocarcinomas. It may also be a useful biomarker for characterizing metaplasia in the intestine and early Barrett esophagus. Hepatocyte Specific Antigen is also found in some gastric adenocarcinomas as well as in a few other non-hepatic tumors. In normal tissue, it has granular cytoplasmic positivity in hepatocytes and small intestine epithelium.
References: Mod Pathol. 2003 Feb;16(2):137-44, PMID: 12591966; Am J Clin Pathol 2012;137:111, PMID: 22180484; Malays J Pathol 2006;28:87, PMID: 18376797
Target
Human Hepatocyte Specific Antigen
Synonyms
HepPar1 | Hep Par | Hepatocyte Paraffin 1 | OCH1E5
Host
Mouse
Reactivity
Human, Dog
(tested or 100% immunogen sequence identity)
Clonality
IgG1
Monoclonal
Clone
HepPar1
Conjugations
Unconjugated
Purification
Protein G purified
Modifications
Unmodified.
Also available Ready-to-Use, Azide-free, BSA-free.
Immunogen
Extract of a formalin-fixed, rejected-allograft of a human liver.
Specificity
Human Hepatocyte Specific Antigen
Applications
- IHC
- IHC - Paraffin (1:50)
- Immunofluorescence (0.5 - 1 µg/ml)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
Hepatocyte Paraffin 1 or HepPar-1 localizes to the mitochondria of hepatocytes. It is a sensitive marker for distinguishing hepatocellular carcinomas (HCC) from other metastatic carcinomas as well as cholangio-carcinomas. HCC s occur primarily in the stomach, but they are also found in many other organs. The Hepatocyte Specific Antigen may also be a useful marker for intestinal metaplasia. Reportedly, strong expression of the Hepatocyte Specific Antigen correlates with smaller tumor size and longer patient survival. Occasionally, Hepatocyte Specific Antigen is also found in gastric carcinomas as well as in a few other non-hepatic tumors. Optimal dilution of the HepPar1 antibody should be determined by the researcher.Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 min.
Presentation
1X PBS, 0.1 mg/ml BSA, 0.05% sodium azide
Storage
Store at 2°C to 8°C.
Restrictions
For research use only. Intended for use by laboratory professionals.
Validation
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
See More About...
LSBio Ratings
PathPlus™ Hepatocyte Specific Antigen Antibody (clone HepPar1) for IHC, IF/Immunofluorescence LS-B16318 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human
Applications:
IHC - Paraffin, IHC - Frozen
Species:
Human, Dog
Applications:
IHC, IHC - Paraffin
Species:
Human, Dog
Applications:
IHC, IHC - Paraffin, Immunofluorescence
Species:
Human, Dog
Applications:
IHC, IHC - Paraffin, Immunofluorescence
Species:
Human, Dog
Applications:
IHC, IHC - Paraffin, Immunofluorescence
Species:
Human, Dog
Applications:
IHC, IHC - Paraffin, Immunofluorescence
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 11/22/2024
Date Requested: 11/22/2024
