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| Catalog Number | Size | Price |
|---|---|---|
| LS-B16283-100 | 100 µg (200 µg/ml) | $525 |
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PathPlus™ Recombinant Monoclonal Rabbit anti‑Human GYPA / CD235a / Glycophorin A Antibody (clone GYPA/1725R, IHC) LS‑B16283
PathPlus™ Recombinant Monoclonal Rabbit anti‑Human GYPA / CD235a / Glycophorin A Antibody (clone GYPA/1725R, IHC) LS‑B16283
Note: This antibody replaces LS-C751166
Antibody:
GYPA / CD235a / Glycophorin A Rabbit anti-Human Recombinant Monoclonal (GYPA/1725R) Antibody
Application:
IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Antibody:
GYPA / CD235a / Glycophorin A Rabbit anti-Human Recombinant Monoclonal (GYPA/1725R) Antibody
Application:
IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Specifications
Description
GYPA (Glycophorin A) is a sialoglycoprotein found on erythrocyte membranes that bears the antigenic determinants for the MNS blood group system. GYPA is also a receptor for a number of viruses such as hepatitis A and influenza and is a target of invasion by the parasite Plasmodium falciparum. In immunohistochemistry, it has membranous staining in erythroblasts and erythroid cells. In cancer, it is used to identify the M6 subtype of acute myeloblastic leukemia and it is also positive in erythroleukemia.
References: Hum Genet. 2018 Feb; 137(2):151-160, PMID: 29362874; Biochem. J. 1983 Jan. 209 (1): 273–6. doi:10.1042/bj2090273, PMID: 6342608; Journal of Human Genetics. 2007 Mar. Volume 52, pages 476–479, DOI: 10.1007/s10038-007-0133-6
Target
Human GYPA / CD235a / Glycophorin A
Synonyms
GYPA | CD235a | CD235a antigen | Glycophorin A (MN blood group) | Glycophorin A, GPA | Glycophorin-A | GPA | GPErik | GPSAT | Glycophorin MiV | Glycophorin SAT | HGpMiX | HGpMiXI | HGpMiV | HGpSta(C) | Glycophorin MiI | GpMiIII | MN | HGpMiIII | MN sialoglycoprotein | Sialoglycoprotein alpha | Mi.V glycoprotein (24 AA) | PAS-2 | Glycophorin A | Glycophorin Sta type C | MNS
Host
Rabbit
Reactivity
Human
(tested or 100% immunogen sequence identity)
Clonality
IgG
Recombinant Monoclonal
Clone
GYPA/1725R
Conjugations
Unconjugated
Purification
Protein A purified
Modifications
Unmodified.
Also available Azide-free, Carrier-free.
Immunogen
Recombinant full-length human GYPA protein. Antigen Molecular Weight: 39 kDa
Specificity
Recognizes a sialoglycoprotein of 39 kDa , identified as glycophorin A (GPA). It is present on red blood cells (RBC) and erythroid precursor cells. It has been shown that glycophorin acts as the receptor for Sandei virus and parvovirus. Glycophorins A (GPA) and B (GPB), which are single, trans-membrane sialoglycoproteins. GPA is the carrier of blood group M and N specificities, while GPB accounts for S and U specificities. GPA and GPB provide the cells with a large mucin like surface and it has been suggested this provides a barrier to cell fusion, so minimizing aggregation between red blood cells in the circulation.
Applications
- IHC - Paraffin (1:100)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
Immunohistology (Formalin-fixed - 0.5-1.0 ug/ml for 30 minutes at RT - Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.) Optimal dilution for a specific application should be determined.
Presentation
10 mM PBS, 0.05% BSA, 0.05% Sodium Azide
Storage
Store at 2°C to 8°C for up to 2 years.
Restrictions
For research use only. Intended for use by laboratory professionals.
About GYPA / CD235a / Glycophorin A
Validation
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
See More About...
LSBio Ratings
PathPlus™ GYPA / CD235a / Glycophorin A Antibody (clone GYPA/1725R) for IHC LS-B16283 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human, Rat
Applications:
IHC - Paraffin, IHC - Frozen, Flow Cytometry
Species:
Human
Applications:
IHC - Paraffin, IHC - Frozen, Flow Cytometry, Agglutination
Species:
Human
Applications:
IHC, IHC - Paraffin, Western blot, Flow Cytometry, ELISA
Species:
Mouse
Applications:
Western blot
Species:
Human
Applications:
IHC, IHC - Paraffin, IHC - Frozen, Flow Cytometry, Cytotoxic Assay
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 11/22/2024
Date Requested: 11/22/2024
