GSTP1 (glutathione S-transferase pi 1) is a gene that encodes multiple functionally different variant proteins that are thought to function in xenobiotic metabolism and also play a role in susceptibility to cancer and other diseases. GSTP1 is considered to be an oncogenic driver and controls metabolic and energetic signaling pathways in triple-negative breast cancer (TNBC), and is of interest as a target of inhibition therapies. In immunohistochemistry of normal tissue, it has cytoplasmic positivity in the biliary tree, renal distal convoluted tubules in the kidney, the lungs, and most other tissues throughout the body. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804; Orphanet J Rare Dis. 2013; 8: 104, PMID: 23844677;