GPR108 (LUSTR2) is a seven-transmembrane family protein that activates NF-?B strongly when overexpressed. It acts as an antagonist of Toll-like receptor (TLR)-mediated signaling. Upon TLR stimulation GPR108 abundance increases and the protein engages TLRs and their partners to reduce MyD88 expression and interfere with its binding to TLR4 through blocking MyD88 ubiquitination. In turn GPR108 is antagonized by TIRAP, an adaptor protein for TLR and MyD88. GPR108 and innate immune signaling components are multifactorial. It is expressed in many tissues in the human body. References: https://doi.org/10.1371/journal.pone.0205303