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| Catalog Number | Size | Price |
|---|---|---|
| LS-A261-50 | 50 µg (1 mg/ml) | $460 |
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PathPlus™ Polyclonal Rabbit anti‑Human F2RL2 / PAR3 Antibody (C‑Terminus, IHC) LS‑A261
PathPlus™ Polyclonal Rabbit anti‑Human F2RL2 / PAR3 Antibody (C‑Terminus, IHC) LS‑A261
Antibody:
F2RL2 / PAR3 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Application:
IHC, IHC-P, ICC
Reactivity:
Human
Format:
Unconjugated, Unmodified
Overview
Antibody:
F2RL2 / PAR3 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Application:
IHC, IHC-P, ICC
Reactivity:
Human
Format:
Unconjugated, Unmodified
Specifications
Description
F2RL2 (PAR3) is a member of the protease-activated receptor (PAR) family of G protein-coupled cell surface receptors. F2RL2 is a cofactor in the thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4. It is essential for hemostasis and thrombosis, and is involved in inflammation and chronic inflammatory diseases. Cathepsin G activation of platelets is also dependent on F2RL2. In immunohistochemistry, F2RL2 has highest membranous positivity on megakaryocytes in bone marrow (with lower positivity in mature megakaryocytes), on patelets, and in other tissues including the heart, gut, retina and brain.
References: Thrombosis J 17, 4 (2019). DOI:10.1186/s12959-019-0194-8
Target
Human F2RL2 / PAR3
Synonyms
F2RL2 | PAR-3 | Thrombin receptor-like 2 | PAR3 | Protease-activated receptor 3
Host
Rabbit
Reactivity
Human
(tested or 100% immunogen sequence identity)
Predicted
Monkey (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 14 amino acid peptide from C-Terminus of human F2RL2. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Gibbon, Monkey (93%); Marmoset (86%).
Epitope
C-Terminus
Specificity
Human F2RL2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
- IHC
- IHC - Paraffin (5 - 10 µg/ml)
- ICC
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Failed Applications
- Western blot
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About F2RL2 / PAR3
Validation
Colon, Carcinoma
Colon, Carcinoma
Pancreas, carcinoma
Pancreas, carcinoma
Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
Breast, Carcinoma
Breast, Carcinoma
See More About...
LSBio Ratings
PathPlus™ F2RL2 / PAR3 Antibody (C-Terminus) for IHC, ICC LS-A261 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human
Applications:
IHC, IHC - Paraffin, Western blot
Species:
Human
Applications:
Immunofluorescence, Peptide Enzyme-Linked Immunosorbent Assay
Reactivity:
Human
Range:
0.312-20 ng/ml
Source:
E. coli
Tag:
His-SUMO
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 7/3/2024
Date Requested: 7/3/2024
