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| Catalog Number | Size | Price |
|---|---|---|
| LS-B7297-50 | 50 µg (1 mg/ml) | $505 |
PathPlus™ Monoclonal Mouse anti‑Human CR2 / CD21 Antibody (clone Bu32, IHC) LS‑B7297
PathPlus™ Monoclonal Mouse anti‑Human CR2 / CD21 Antibody (clone Bu32, IHC) LS‑B7297
Note: This antibody replaces LS-C44921
Antibody:
CR2 / CD21 Mouse anti-Human Monoclonal (Bu32) Antibody
Application:
IHC, IHC-P, IP, Flo
Reactivity:
Human
Format:
Unconjugated, Unmodified
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Antibody:
CR2 / CD21 Mouse anti-Human Monoclonal (Bu32) Antibody
Application:
IHC, IHC-P, IP, Flo
Reactivity:
Human
Format:
Unconjugated, Unmodified
Specifications
Description
CD21 (Complement receptor type 2, CR2) is a receptor glycoprotein localized to the surface of B-cells. CD21 recognizes a number of ligands including CD23, interferon-alpha and complement component C3 fragments. Functionally, CD21 regulates B-cell activation and maturation and acts as a mediator between adaptive immunity and the complement system. In immunohistochemistry, CD21 shows positive membranous staining in mature B cells, plasma cells, follicular dendritic cells of the tonsil and lymph nodes, subsets of T-cells, and subsets of B cell lymphomas and angioimmunoblastic T-cell lymphoma.
References: International Journal of Research in Medical Sciences. 2017;5:1156, DOI: 10.18203/2320-6012.ijrms20171218; Curr Protein Pept Sci. 2016;17(5):463-87, PMID: 26916158
Target
Human CR2 / CD21
Synonyms
CR2 | C3DR | CD21 antigen | CVID7 | Complement receptors type 2 | CD21 | Complement C3d receptor | EBV receptor | SLEB9 | Complement receptor type 2 | CR | Epstein-Barr virus receptor
Host
Mouse
Reactivity
Human
(tested or 100% immunogen sequence identity)
Clonality
IgG1
Monoclonal
Clone
Bu32
Conjugations
Unconjugated
Purification
Protein G purified
Modifications
Unmodified
Immunogen
Human lymphocytes.
Specificity
Recognizes human CD21, a 145kD cell surface glycoprotein expressed by mature B lymphocytes, follicular dendritic cells, subsets of normal thymocytes and subsets of T cells. The CD21 molecule acts as a receptor for complement components C3d, C3dg and iC3b, as well as for Epstein Barr Virus. CD21 is part of the signalling complex that is linked to CD19, CD81 and phosphatidylinositol-3-kinase.
Applications
- IHC
- IHC - Paraffin (10 µg/ml)
- Immunoprecipitation
- Flow Cytometry (1:50 - 1:200)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
Flow Cytometry: Use 10 ul of the suggested working dilution to label 1x10^6 cells in 100 ul.
Presentation
PBS, pH 7.4, 0.09% Sodium Azide
Storage
Short term: store at 4°C. Long term: aliquot and store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About CR2 / CD21
Validation
Anti-CR2 / CD21 antibody IHC of human tonsil, germinal center. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-CR2 / CD21 antibody IHC of human tonsil, germinal center. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
See More About...
LSBio Ratings
PathPlus™ CR2 / CD21 Antibody (clone Bu32) for IHC, IP, Flow LS-B7297 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
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Featured Products
Species:
Human
Applications:
IHC, IHC - Paraffin, Flow Cytometry
Species:
Human
Applications:
Western blot, Flow Cytometry, Functional Assay
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 12/21/2024
Date Requested: 12/21/2024
