E-cadherin (CDH1) is a calcium-depending glycoprotein that is involved in cell to cell adhesion and is expressed on the surface of epithelial tissues. Loss of e-cadherin is associated with decreased cell adhesion, increased cellular motility, invasion and poor prognosis in carcinomas, particularly lobular carcinomas of the breast. In immunohistochemistry, e-cadherin is positive in normal breast ducts, the epithelium of the GI tract, hepatocytes and bile ducts. In cancer, it is positive in breast ductal carcinoma (but not lobular), esophageal adenocarcinoma and squamous carcinoma, and bladder transitional cell carcinoma. References: Eur J Cancer 2000, 36:1607; Cell. 2015 Oct 8;163(2):506-19, PMID: 26451490; Breast Cancer Res. 2017 Jul 27;19(1):86, PMID: 28750639; Oncotarget 2017 Jan; 8.1; 16445-16455, PMID: 28147315; Oncotarget. 2016 Nov; 7.49; 80655-80663, PMID: 27811364;