CD7 is a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is found on thymocytes, mature T cells, monocytes, pluripotent hematopoietic progenitor cells, early myeloid cells, and pre-B cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development. CD7 is an effective marker for T-cell Acute Lymphoblastic Leukemia (T-ALL). Furthermore, positive expression of CD7 is considered a marker of poor prognosis in myeloid malignancies and in cytotoxic T-cell lymphoma, while loss of CD7 indicates poor prognosis in FLT3/ITD-mutant positive acute myelogenous leukemia, adult T-cell leukemia and lymphoma, aggressive NK cell lymphoma and HTLV1. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804; Int J Hematol 2010;91:303, PMID: 20111912; Am J Surg Pathol 2003;27:1366, PMID: 14508398;