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| Catalog Number | Size | Price |
|---|---|---|
| LS-B16233-100 | 100 µg (200 µg/ml) | $525 |
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PathPlus™ Recombinant Monoclonal Rabbit anti‑Human CD1A Antibody (clone C1A/1506R, IHC) LS‑B16233
PathPlus™ Recombinant Monoclonal Rabbit anti‑Human CD1A Antibody (clone C1A/1506R, IHC) LS‑B16233
Note: This antibody replaces LS-C751437
Antibody:
CD1A Rabbit anti-Human Recombinant Monoclonal (C1A/1506R) Antibody
Application:
IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Antibody:
CD1A Rabbit anti-Human Recombinant Monoclonal (C1A/1506R) Antibody
Application:
IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Specifications
Description
CD1a (LEU6) is an MHC class I-related glycoprotein of the CD1 family expressed on the surface of Langerhans or dendritic cells. CD1A proteins present antigens to T-cells in order to induce an immune response to certain pathogens. In addition to the response to bacterial invasion, CD1a-reactive cells have also found to regulate the immune response in individuals with bee and wasp venom allergies. Likewise, there is evidence that CD1a regulates and amplifies the inflammatory response in a number of inflammatory skin diseases. In immunohistochemistry, CD1A has membranous staining in cortical thymocytes, interdigitating reticulum cells and Langerhans cells. In cancer, CD1A stains positively in thymomas, precursor T-lymphoblastic leukemia or lymphoma, and Langerhans cell histiocytosis X.
References: Eur J Immunol. 2016 Jan;46(1):56-9, PMID: 26617406; Nat Immunol. 2016 Oct;17(10):1159-66, PMID: 27548435; J Immunol. 2008 Jan 15;180(2):980-7, PMID: 18178838; J Clin Invest. 2004 Mar 1; 113(5): 658–660, PMID: 14991060
Target
Human CD1A
Synonyms
CD1A | CD1 | CD1A antigen, a polypeptide | CD1a molecule | FCB6 | HTA1 | HTa1 thymocyte antigen | R4 | T6 | CD1a antigen | Cluster of differentiation 1 A
Host
Rabbit
Reactivity
Human
(tested or 100% immunogen sequence identity)
Clonality
IgG
Recombinant Monoclonal
Clone
C1A/1506R
Conjugations
Unconjugated
Purification
Protein A purified
Modifications
Unmodified.
Also available Azide-free, Carrier-free.
Immunogen
Recombinant full-length human CD1a protein. Antigen Molecular Weight: 49 kDa
Specificity
At least five CD1 genes (CD1a, b, c, d, and e) are identified. CD1 proteins have been demonstrated to restrict T cell response to non-peptide lipid and glycolipid antigens and play a role in non-classical antigen presentation. CD1a is a non-polymorphic MHC Class 1 related cell surface glycoprotein, expressed in association with Beta-2 microglobulin. Anti-CD1a labels Langerhans cell histiocytosis (Histiocytosis X), extranodal histiocytic sarcoma, a subset of T-lymphoblastic lymphoma/leukemia, and interdigitating dendritic cell sarcoma of the lymph node. When combined with antibodies against TTF-1 and CD5, anti-CD1a is useful in distinguishing between pulmonary and thymic neoplasms since CD1a is consistently expressed in thymic lymphocytes in both typical and atypical thymomas, but only focally in 1/6 of thymic carcinomas and not in lymphocytes in pulmonary neoplasms. Anti-CD1a is reported to be a new marker for perivascular epithelial cell tumor (PEComa).
Applications
- IHC - Paraffin (1:50)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
Immunohistology (Formalin-fixed - 0.5-1 ug/ml for 30 min at RT - Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.) Optimal dilution for a specific application should be determined.
Presentation
10 mM PBS, 0.05% BSA, 0.05% Sodium Azide
Storage
Store at 2°C to 8°C for up to 2 years.
Restrictions
For research use only. Intended for use by laboratory professionals.
About CD1A
Validation
Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)
See More About...
LSBio Ratings
PathPlus™ CD1A Antibody (clone C1A/1506R) for IHC LS-B16233 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human, Monkey, Dog, Cynomolgus
Applications:
IHC, IHC - Frozen, Flow Cytometry
Species:
Human
Applications:
IHC, IHC - Frozen, Flow Cytometry
Species:
Human, Mouse, Rat
Applications:
IHC - Paraffin, Immunofluorescence
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 11/22/2024
Date Requested: 11/22/2024
