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ADRB2
adrenoceptor beta 2, surface
ADRB2 is beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes.
| Gene Name: | adrenoceptor beta 2, surface |
| Family/Subfamily: | GPCR , Adrenergic |
| Synonyms: | ADRB2, ADRB2R, Adrenoceptor beta 2, surface, ADRBR, B2AR, Beta-2 adrenoceptor, Beta-2 adrenergic receptor, Beta-2 adrenoreceptor, BETA2AR, BAR, Adrenergic beta-2 receptor, Catecholamine receptor |
| Target Sequences: | NM_000024 NP_000015.1 P07550 |
Publications (4)
1
Matrix metalloproteinases cleave the beta2-adrenergic receptor in spontaneously hypertensive rats. Rodrigues SF, Tran ED, Fortes ZB, Schmid-Schnbein GW. American journal of physiology. Heart and circulatory physiology. 2010 299:H25-35.
[PubMed:20382857]
[PMC:PMC2904131]
2
ß-Adrenergic receptor subtype expression in myocyte and non-myocyte cells in human female bladder. Limberg BJ, Andersson KE, Aura Kullmann F, Burmer G, de Groat WC, Rosenbaum JS. Cell and tissue research. 2011 317:107-16. (ICC, IHC-P; Human)
[Full Text Article]
[PubMed:20953633]
[PMC:PMC3113530]
Related Antibodies: LS-A2662.
3
Flow Cytometry of Mouse and Human Adipocytes for the Analysis of Browning and Cellular Heterogeneity. Hagberg CE, Li Q, Kutschke M, Bhowmick D, Kiss E, Shabalina IG, Harms MJ, Shilkova O, Kozina V, Nedergaard J, Boucher J, Thorell A, Spalding KL. Cell reports. 2018 September;24:2746-2756. [Full Text Article]
[PubMed:30184507]
[PMC:PMC6137819]
Related Antibodies: LS-C274967.
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(87)
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(5)
Target
ADRB2
(104)
Reactivity
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(87)
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(37)
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(25)
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(4)
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(3)
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(1)
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(1)
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(2)
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(7)
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aa330-418
(4)
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(2)
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(2)
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(1)
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(1)
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(1)
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(1)
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(1)
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(1)
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(1)
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(1)
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(1)
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(1)
Publications
No
(101)
Yes
(3)
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(4)
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(3)
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(3)
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(3)
Tag
6His-SUMO, N-terminus
(1)
GST
(1)
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(2)
Species
Human
(3)
Source
293T Cells
(1)
E. coli
(1)
HEK 293 Cells
(1)
Wheat Germ Extract
(1)
Purification
Purified
(2)
ADRB2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
ICC, IHC, IHC-P
Unconjugated
50 µg/$440
ADRB2 Goat anti-Human Polyclonal (aa390-402) Antibody
Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µg/$503
ADRB2 Mouse anti-Human Monoclonal (13A16) Antibody
Guinea pig, Rat, Human
ELISA, Flo, Func
Unconjugated
100 µg/$866
ADRB2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Dog, Sheep, Bovine, Rat, Human
WB
Unconjugated
100 µl/$299
ADRB2 Chicken anti-Human Polyclonal (aa335-408) Antibody
Rabbit, Mouse, Dog, Guinea pig, Sheep, Bovine, Rat, Hamster, Horse, Human, Monkey
WB
Unconjugated
50 µg/$807
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$783
ADRB2 Rabbit anti-Human Polyclonal (300-380 aa) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
ADRB2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
ADRB2 Rabbit anti-Human Polyclonal (aa321-370) Antibody
Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
ADRB2 Rabbit anti-Human Polyclonal (pSer346) Antibody
Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
ADRB2 Rabbit anti-Human Polyclonal (Ser364) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
200 µl/$734
ADRB2 Rabbit anti-Human Polyclonal (Ser364) (FITC) Antibody
Human
ELISA, Flo, IHC, WB
FITC Conjugated
200 µl/$952
ADRB2 Rabbit anti-Human Polyclonal (Ser364) (APC) Antibody
Human
ELISA, FLISA, WB
APC Conjugated
200 µl/$952
Fast Shipping
ADRB2 Rabbit anti-Human Polyclonal (Transmembrane Domain) Antibody
Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
Cell-Based Phosphorylation
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
ADRB2 Rabbit anti-Human Polyclonal (aa336-385) Antibody
Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
ADRB2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
ADRB2 Rabbit anti-Human Polyclonal (pSer355/356) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
ADRB2 Rabbit anti-Human Polyclonal (300-380 aa) Antibody
Mouse, Rat, Human, Monkey
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
ADRB2 Rabbit anti-Human Polyclonal (aa3-21) Antibody
Human
IHC, IP, WB
Unconjugated
50 µl/$393
ADRB2 Rabbit anti-Human Polyclonal (aa201-250) Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
ADRB2 Mouse anti-Human Monoclonal (6H8) Antibody
Guinea pig, Rat, Human
Flo, Func
Unconjugated
100 µg/$589
ADRB2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IP, WB
Unconjugated
100 µl/$749
ADRB2 Rabbit anti-Human Polyclonal (pSer346) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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