FOXA2 (forkhead box protein A2, HNF-3B, TCF-3B) is a transcription factor that activates albumin, transthyretin and other liver-specific genes. It is involved in the differentiation of cells in the pancreas and liver, lipid metabolic regulation and ketogenesis. FOXA2 also plays an important role in the maintenance of dopamine neurons in adults, and it is required for the proper differentiation of mesodiencephalic dopaminergic neurons during development. Downregulation of FOXA2 is implicated in lipid accumulation and insulin resistance in the liver in fasting and diabetes. Lowered levels of FOXA2 are also correlated with invasive properties in hepatocellular carcinoma. In immunohistochemistry of normal adult tissue, FOXA2 primarily has nuclear positivity in the pancreas, liver, lung, gastrointestinal tract, urinary bladder, prostate, endometrium, fallopian tube and appendix. References: Nature. 2004 Dec 23;432(7020):1027-32, PMID: 15616563; Carcinogenesis. 2014. 35(11): 2576–2583, DOI: 10.1093/carcin/bgu180; Journal of Neuroscience. 2013. 33 (18): 8022-8034, DOI: 10.1523/JNEUROSCI.4774-12.2013; Front Cell Neurosci. 2014; 8: 275, PMID: 25249938;