XRCC5 / Ku80

X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)

Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. In association with NAA15, the XRCC5/6 dimer binds to the osteocalcin promoter and activates osteocalcin expression. The XRCC5/6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription.

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Products

Antibodies (87)

Proteins (8)

ELISA Kits (6)

Type

Cell-Based (2)

Cell-Based Phosphorylation (1)

Development Kit (1)

Over-Expression Lysate (2)

Primary (87)

Recombinant (6)

Sandwich (2)

Target

XRCC5 / Ku80 (101)

Reactivity

Human (92)

Mouse (23)

Rat (4)

Bat (3)

Chimpanzee (3)

Gibbon (3)

Hamster (2)

Horse (3)

Monkey (9)

Orangutan (3)

Pig (3)

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Application

IHC (44)

IHC-P (25)

WB (79)

Flo (10)

ELISA (28)

ICC (16)

IF (22)

IP (7)

Peptide-ELISA (6)

Host

rabbit (72)

mouse (14)

goat (1)

Product Group

DevKit DuoPlus (1)

IHCPlus (4)

Isotype

IgG (43)

IgG1 (6)

IgG1,k (1)

IgG2a (3)

Clonality

monoclonal mc (13)

polyclonal pc (74)

Clone

149.8 (1)

3D8 (1)

5C5 (2)

9403 (1)

MEM-54 (2)

Format

96-Well Microplate (3)

96-Well Strip Plate (2)

Antibody Pair and Standard (1)

APC (2)

APC Conjugated (3)

Azide-free (2)

Biotin Conjugated (6)

Cy3 Conjugated (2)

Cy7 Conjugated (2)

FITC Conjugated (6)

HRP Conjugated (6)

PE Conjugated (3)

Preservative Free (1)

Unconjugated (59)

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Epitope

C-Terminus (9)

aa2-460 (8)

aa251-732 (8)

aa431-458 (6)

N-Terminus (2)

aa683-732 (2)

pThr714 (2)

410-490 aa, Internal (1)

660-740 aa (1)

660-740 aa, C-terminal (1)

Acetyl-Lys565 (1)

Ala717 (1)

Asp708 (1)

Internal (1)

Ser145 (1)

Ser462 (1)

aa1-210 (1)

aa1-733 (1)

aa150-200 (1)

aa315-593 (1)

aa413-462 (1)

aa441-490 (1)

aa462-475 (1)

aa543-732 (1)

aa648-662 (1)

aa649-676 (1)

p714 (1)

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Publications

No (101)

Sample Type

Adherent Cell Cultures (3)

Tissue Homogenates (3)

Tag

10His, N-terminus + Myc, C-terminus (1)

GST (1)

His (2)

His-T7 (1)

MBP, N-terminus + 6His, C-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (6)

Mouse (1)

Source

293T Cells (1)

Baculovirus (1)

E. coli (4)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (3)

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IHC-plus™ XRCC5 / Ku80 Antibody (aa462-475) LS-B2584

(4.0) Rating

Antibody:

XRCC5 / Ku80 Goat anti-Human Polyclonal (aa462-475) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µg/$485

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IHC-plus™ XRCC5 / Ku80 Antibody (clone 5C5) LS-B11679

(4.0) Rating

Antibody:

XRCC5 / Ku80 Mouse anti-Human Monoclonal (5C5) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

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IHC-plus™ XRCC5 / Ku80 Antibody (C-Terminus, clone 149.8) LS-B1718

(4.0) Rating

Antibody:

XRCC5 / Ku80 Mouse anti-Human Monoclonal (C-Terminus) (149.8) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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Human XRCC5 / Ku80 Protein (Recombinant His) (aa2-460) - LS-G25198

Source:

E. coli

Tag:

His

Molecular Weight:

55.7 kDa

Price:

10 µg/$279; 50 µg/$430; 100 µg/$687; 200 µg/$857; 1 mg/$1,956; 500 µg/$1,499; 5 mg/$2,997; 2 mg/$2,142

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XRCC5 / Ku80 Antibody (C-Terminus) LS-C31766

Antibody:

XRCC5 / Ku80 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$397

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XRCC5 / Ku80 Antibody (aa683-732) LS-C117623

Antibody:

XRCC5 / Ku80 Rabbit anti-Human Polyclonal (aa683-732) Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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IHC-plus™ XRCC5 / Ku80 Antibody (N-Terminus, clone 9403) LS-B1719

(4.0) Rating

Antibody:

XRCC5 / Ku80 Mouse anti-Human Monoclonal (N-Terminus) (9403) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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XRCC5 / Ku80 Antibody LS-C393641

Antibody:

XRCC5 / Ku80 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ICC, IP, WB

Format:

Unconjugated

Price:

100 µl/$391

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XRCC5 / Ku80 Antibody (clone 5C5) LS-C758950

Antibody:

XRCC5 / Ku80 Mouse anti-Human Monoclonal (5C5) Antibody

Reactivity:

Mouse, Human

Applications:

Flo, ICC, IF, IHC, WB

Format:

Unconjugated

Price:

100 µl/$541

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XRCC5 / Ku80 Antibody (aa441-490) LS-C119556

Antibody:

XRCC5 / Ku80 Rabbit anti-Human Polyclonal (aa441-490) Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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XRCC5 / Ku80 Antibody LS-C812678

Antibody:

XRCC5 / Ku80 Mouse anti-Human Monoclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, Flo, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$332; 100 µg/$404; 200 µg/$505

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XRCC5 / Ku80 Antibody (C-Terminus) LS-C368653

Antibody:

XRCC5 / Ku80 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human, Monkey

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

30 µl/$263; 50 µl/$279; 100 µl/$315; 200 µl/$379

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XRCC5 / Ku80 Antibody (C-Terminus) LS-C353017

Antibody:

XRCC5 / Ku80 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human, Monkey

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

30 µl/$255; 50 µl/$271; 100 µl/$299; 200 µl/$351

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XRCC5 / Ku80 Antibody (C-Terminus) LS-C413046

Antibody:

XRCC5 / Ku80 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human, Monkey

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

30 µl/$266; 50 µl/$286; 100 µl/$321; 200 µl/$386

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XRCC5 / Ku80 Antibody LS-C334351

Antibody:

XRCC5 / Ku80 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF, IHC, IP, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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XRCC5 / Ku80 Antibody (p714) LS-C826070

Antibody:

XRCC5 / Ku80 Rabbit anti-Human Polyclonal (p714) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µl/$357

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XRCC5 / Ku80 Antibody (phospho-Thr714) LS-C826072

Antibody:

XRCC5 / Ku80 Rabbit anti-Human Polyclonal (pThr714) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µl/$357

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XRCC5 / Ku80 Antibody LS-C415898

Antibody:

XRCC5 / Ku80 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ICC, IF, IHC, WB

Format:

Unconjugated

Price:

50 µl/$305; 100 µl/$357

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XRCC5 / Ku80 Antibody (aa315-593) LS-C186112

Antibody:

XRCC5 / Ku80 Rabbit anti-Human Polyclonal (aa315-593) Antibody

Reactivity:

Human

Applications:

ICC, IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

100 µl/$450

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XRCC5 / Ku80 Antibody (aa648-662) LS-C312798

Antibody:

XRCC5 / Ku80 Rabbit anti-Human Polyclonal (aa648-662) Antibody

Reactivity:

Human, Monkey

Applications:

ICC, IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

Select

XRCC5 / Ku80 Antibody (phospho-Thr714) LS-C199178

Antibody:

XRCC5 / Ku80 Rabbit anti-Human Polyclonal (pThr714) Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

XRCC5 / Ku80 Antibody (660-740 aa) LS-C381464

Antibody:

XRCC5 / Ku80 Rabbit anti-Human Polyclonal (660-740 aa) Antibody

Reactivity:

Human, Monkey

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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XRCC5 / Ku80 Antibody (aa431-458, Biotin) LS-C273743

Antibody:

XRCC5 / Ku80 Rabbit anti-Human Polyclonal (aa431-458) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IF, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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XRCC5 / Ku80 Antibody (aa431-458, APC) LS-C273742

Antibody:

XRCC5 / Ku80 Rabbit anti-Human Polyclonal (aa431-458) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IF, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

XRCC5 / Ku80 Antibody (aa431-458, PE) LS-C273748

Antibody:

XRCC5 / Ku80 Rabbit anti-Human Polyclonal (aa431-458) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IF, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Biotin
• APC
• PE

• Biotin
• APC
• PE

Viewing 1-25 of 101 product results

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