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Catalog Number Size Price
LS-C500123-50 50 µg $294 
LS-C500123-100 100 µg $360 
Antibody

Polyclonal Rabbit anti‑Human XBP1 Antibody (Biotin) LS‑C500123

Polyclonal Rabbit anti‑Human XBP1 Antibody (Biotin) LS‑C500123

Antibody:
XBP1 Rabbit anti-Human Polyclonal (Biotin) Antibody
Application:
ELISA
Reactivity:
Human
Format:
Biotin, Unmodified
Other formats:
Price
Catalog Number
$294
LS-C500123-50
Toll Free North America
(800) 227-6666
For Research Use Only

Overview

Antibody:
XBP1 Rabbit anti-Human Polyclonal (Biotin) Antibody
Application:
ELISA
Reactivity:
Human
Format:
Biotin, Unmodified
Other formats:

Specifications

Description
XBP1 antibody LS-C500123 is a biotin-conjugated rabbit polyclonal antibody to human XBP1. Validated for ELISA.
Target
Human XBP1
Synonyms
XBP1 | X-box binding protein 1 | X-box-binding protein 1 | XBP2 | TREB5 | XBP-1
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Biotin. Also available Unconjugated or conjugated with HRP, FITC.
Purification
Protein G purified
Modifications
Unmodified
Immunogen
Recombinant Human X-box-binding protein 1 protein (1-167AA)
Specificity
Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development, and the development of secretory tissues such as exocrine pancreas and salivary gland (By similarity). Involved in terminal differentiation of B lymphocytes to plasma cells and production of immunoglobulins (PubMed:11460154). Modulates the cellular response to ER stress in a PIK3R-dependent manner (PubMed:20348923). Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes (PubMed:8349596). Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions. Functions also as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for the management of obesity and diabetes prevention (By similarity).
Applications
  • ELISA
  • Applications tested for the base form of this product only
Presentation
PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Storage
Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About XBP1
P17861 NM_005080 NP_005071.2

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Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 12/5/2024