Target
Human TP63 / p63
Synonyms
TP63 | B(p51B) | CUSP | AIS | EEC3 | KET | NBP | OFC8 | p73L | p73H | RHS | SHFM4 | LMS | TP53CP | Tumor protein 63 | Tumor protein p53-like | Tumor protein p73-like | TP73L | p51 | B(p51A) | Tumor protein p63 | p40 | p53CP | p63 | TP53L
Reactivity
Human
(tested or 100% immunogen sequence identity)
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Immunogen
Human partial recombinant protein (aa311-680).
Specificity
Human TP63 / p63
Applications
- IHC
- IHC - Paraffin (0.5 - 1 µg/ml)
- ICC (0.5 - 1 µg/ml)
- Western blot (0.5 - 1 µg/ml)
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Usage
Tumor protein p63 (TP63), also known as TP73L is a protein that in humans is encoded by the TP63 gene. It is a member of the p53 family of transcription factors. This gene encodes for two main isoforms by alternative promoters (TAp63 and dNp63). TP63 has been mostly restricted to its apoptotic function and more recently as the guardian of oocyte integrity. It has been found that the combined loss of TP63 and p73 results in the failure of cells containing functional p53 to undergo apoptosis in response to DNA damage. It is an essential regulator of stem cell maintenance in stratified epithelial tissues. TP63 is also critical for maintaining the progenitor-cell populations that are necessary to sustain epithelial development and morphogenesis.
Presentation
Lyophilized from PBS, 2.5% BSA, 0.025% sodium azide.
Reconstitution
Reconstitute in sterile distilled water.
Storage
Prior to reconstitution, 4°C. Following reconstitution store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee