Human TNFRSF12A / TWEAK Receptor

Mouse

Human (tested or 100% immunogen sequence identity)

IgG2b Monoclonal

ITEM-4

Unconjugated. Also available conjugated with RPE.

Protein G purified

Unmodified

Human CD266 transfected P815 cells.

Recognizes human CD266, otherwise known as Fn14/TWEAK Receptor, a 14kD type I transmembrane glycoprotein and member of the tumor necrosis factor receptor superfamily (TNFRSF12A) expressed by a variety of tissues, including the heart, lung and kidney, and at elevated levels by human brain and liver tumors. The interaction between CD266 and its ligand CD255 (TWEAK), induces the proliferation and migration of endothelial cells and also angiogenesis, and studies have shown that CD255-induced apoptosis of some tumor cell lines is mediated by CD266. Clone ITEM-4 is cross-reactive with mouse CD266, and also with Rat-1 cells in flow cytometry.

• IHC
• IHC - Frozen
• Western blot
• Flow Cytometry (1:25 - 1:200)

PBS, 0.09% Sodium Azide

Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: Q9NP84 NCBI: NM_016639 NP_057723.1