Human TLR3

Rabbit

Human (tested or 100% immunogen sequence identity)

IgG Polyclonal

Unconjugated

Purified

Unmodified

Synthetic peptide corresponding to a 15 amino acid sequence located near human CD283 C-Terminus

C-Terminus

Recognizes human CD283, otherwise known as toll receptor 3, a 103.8 kD member of the evolutionarily conserved toll-like receptor family (TLRs), expressed at high levels in the placenta and pancreas and also expressed by dendritic cells. TLRs play an important role in the recognition of invading microbial pathogens during innate immunity, acting through adaptor molecules such as MyD88 and TRAF6. CD283 acts via a cytokine signaling pathway to induce the activation of NF-kappaB and type I interferons, and has been shown to recognize double-stranded viral RNA, including that of the Influenza A and West Nile virus. Has been shown as suitable for use in IHC on EL4 cytospins at 1 ug/ml.

• IHC - Frozen
• Western blot (1 - 2 µg/ml)

Western Blot: LS-C42338 detects a band of approximately 103.8kD in human Daudi cell lysates.

PBS, 0.02% Sodium Azide

Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: O15455 NCBI: NM_003265 NP_003256.1