Human TFF1 / pS2

Mouse

Human (tested or 100% immunogen sequence identity)

IgG1,k Monoclonal

BCEIP1

Unconjugated

Protein G purified

Azide-free, BSA-free. Also available Unmodified or Ready-to-Use.

C-Terminus peptide

C-Terminus

Human TFF1 / PS2

• IHC
• IHC - Paraffin (1 - 2 µg/ml)
• Immunofluorescence (0.5 - 1 µg/ml)

The applications listed have been tested for the unmodified form of this product. Other forms have not been tested. TFF1/Breast cancer estrogen inducible protein pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. TFF1/pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. TFF1 is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Titering of the TFF1 antibody may be required for optimal performance. FFPE testing requires sections to be boiled in pH6 10mM citrate buffer for 10-20 minutes, followed by cooling at RT for 20 minutes, prior to staining.

1X PBS

Store at 2°C to 8°C.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P04155 NCBI: NM_003225 NP_003216.1