SOCS5

suppressor of cytokine signaling 5

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling.

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Products

Antibodies (9)

Proteins (6)

Type

Over-Expression Lysate (4)

Primary (9)

Recombinant (2)

Target

SOCS5 (15)

Reactivity

Human (9)

Mouse (5)

Rat (2)

Application

IHC (4)

IHC-P (3)

WB (7)

ELISA (6)

IF (1)

Host

rabbit (8)

mouse (1)

Isotype

IgG (7)

IgG1,k (1)

Clonality

monoclonal mc (1)

polyclonal pc (8)

Clone

2D1 (1)

Format

Unconjugated (9)

Publications

No (14)

Yes (1)

Tag

GST (1)

His, N-Terminal (1)

Myc-DDK (Flag) (4)

Species

Human (4)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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SOCS5 Antibody LS-C409498

(4.0) Rating

(1) Publication(s)

Antibody:

SOCS5 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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SOCS5 Antibody (clone 2D1) LS-C133600

Antibody:

SOCS5 Mouse anti-Human Monoclonal (2D1) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$423

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SOCS5 Antibody LS-C676537

Antibody:

SOCS5 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

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SOCS5 Antibody LS-C754068

Antibody:

SOCS5 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$406

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SOCS5 Antibody LS-C676540

Antibody:

SOCS5 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

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SOCS5 Antibody LS-C404296

Antibody:

SOCS5 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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SOCS5 Antibody LS-C779938

Antibody:

SOCS5 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µl/$357

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SOCS5 Antibody LS-C770805

Antibody:

SOCS5 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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SOCS5 Antibody LS-C809

Antibody:

SOCS5 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

200 µl/$386

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Human SOCS5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89866

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

61.1 kDa

Price:

20 µg/$150

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Human SOCS5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89865

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

61.1 kDa

Price:

20 µg/$150

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Human SOCS5 Protein (Recombinant His, N-Terminal) - LS-G144070

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

61.1 kDa

Price:

50 µg/$419

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SOCS5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G106811

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

61.1 kDa

Price:

100 µg/$494

Select

SOCS5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101152

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

61.1 kDa

Price:

100 µg/$494

Select

Human SOCS5 Protein (Recombinant GST) (Full Length) - LS-G31752

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

87.6 kDa

Price:

10 µg/$479; 25 µg/$670

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