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Catalog Number Size Price
LS-C502012-50 50 µg $294 
LS-C502012-100 100 µg $360 
SIRT7 / Sirtuin 7 Antibody - Immunohistochemistry of paraffin-embedded human kidney tissue using SIRT7 Antibody at dilution of 1:100
SIRT7 / Sirtuin 7 Antibody - Immunofluorescent analysis of Hela cells using SIRT7 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
SIRT7 / Sirtuin 7 Antibody - Immunofluorescent analysis of Hela cells using SIRT7 Antibody at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
SIRT7 / Sirtuin 7 Antibody - Immunohistochemistry of paraffin-embedded human kidney tissue using SIRT7 Antibody at dilution of 1:100
SIRT7 / Sirtuin 7 Antibody - Immunofluorescent analysis of Hela cells using SIRT7 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
SIRT7 / Sirtuin 7 Antibody - Immunofluorescent analysis of Hela cells using SIRT7 Antibody at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Polyclonal Rabbit anti‑Human SIRT7 / Sirtuin 7 Antibody (IHC, IF) LS‑C502012

Polyclonal Rabbit anti‑Human SIRT7 / Sirtuin 7 Antibody (IHC, IF) LS‑C502012

Antibody:
SIRT7 / Sirtuin 7 Rabbit anti-Human Polyclonal Antibody
Application:
IHC, IF, ELISA
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$294
LS-C502012-50
Toll Free North America
(800) 227-6666
For Research Use Only

Overview

Antibody:
SIRT7 / Sirtuin 7 Rabbit anti-Human Polyclonal Antibody
Application:
IHC, IF, ELISA
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
Sirtuin 7 antibody LS-C502012 is an unconjugated rabbit polyclonal antibody to human Sirtuin 7 (SIRT7). Validated for ELISA, IF and IHC.
Target
Human SIRT7 / Sirtuin 7
Synonyms
SIRT7 | SIR2L7 | Sirtuin type 7 | SIR2-like protein 7 | Sir2-related protein type 7 | Sirtuin 7
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated. Also available conjugated with HRP, FITC, Biotin.
Purification
Protein G purified
Modifications
Unmodified
Immunogen
Recombinant Human NAD-dependent protein deacetylase sirtuin-7 protein (242-379AA)
Specificity
NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation.
Applications
  • IHC
  • Immunofluorescence
  • ELISA
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Presentation
PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Storage
Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About SIRT7 / Sirtuin 7
Q9NRC8 NM_016538 NP_057622.1

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Requested From: United States
Date Requested: 12/15/2024