Target
Human SIP / TP53INP1
Synonyms
TP53INP1 | p53DINP1 | SIP | Teap | TP53DINP1 | TP53INP1A | p53-inducible p53DINP1 | Stress-induced protein | TP53INP1B
Reactivity
Human
(tested or 100% immunogen sequence identity)
Immunogen
Recombinant Human Tumor protein p53-inducible nuclear protein 1 protein (138-205AA)
Specificity
Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.