Target
Human SIGLEC7 / CD328
Synonyms
SIGLEC7 | AIRM-1 | AIRM1 | CD328 antigen | CDw328 | CD328 | D-siglec | QA79 | SIGLEC-7 | QA79 membrane protein
Reactivity
Human
(tested or 100% immunogen sequence identity)
Conjugations
R. Phycoerythrin.
Also available
Unconjugated or conjugated with
FITC.
Immunogen
Monocyte-derived dendritic cells
Specificity
Specific for human CDw328, a type I transmembrane glycoprotein and member of the Siglec (sialic acid binding Ig-like lectin) family, designated Siglec-7, originally identified as an inhibitory NK cell receptor (NKR) and negative regulator of NK activation, attributed to ITIM recruitment of SHP-1 phosphatase. CDw328 is expressed predominantly by natural killer cells (NK) and to a lesser extent by monocytes and granulocytes and, like Siglec-5 (CD170), has been shown to bind to sialylated ligands of targets through recognition of sialic acid in both the alpha-2,3- and alpha-2,6- glycosidic linkage.