Human PLEKHO1 / CKIP-1

Rabbit

Human (tested or 100% immunogen sequence identity)

IgG Polyclonal

Unconjugated. Also available conjugated with FITC, Biotin, HRP.

Protein G purified

Unmodified

Recombinant Human Pleckstrin homology domain-containing family O member 1 protein (143-404AA)

Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.

• Immunofluorescence
• ELISA

PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.

Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: Q53GL0 NCBI: NM_016274 NP_057358.2