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Catalog Number	Size	Price
LS-C501236-50	50 µg	$294
LS-C501236-100	100 µg	$360

PARG Antibody - Immunofluorescent analysis of PC3 cells using PARG Antibody at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Polyclonal Rabbit anti‑Human PARG Antibody (IF) LS‑C501236

Name: Anti-PARG Antibody | Rabbit anti-Human Polyclonal ELISA,IF | LSBio
Brand: Lifespan BioSciences
SKU: LS-C501236-50
Price: 294.0000 USD
Availability: InStock

Submit Review LSBio Guarantee

Antibody:

PARG Rabbit anti-Human Polyclonal Antibody

Application:

IF, ELISA

Reactivity:

Human

Format:

Unconjugated, Unmodified

Other formats:

HRP FITC Biotin

$294

LS-C501236-50

Toll Free North America

(800) 227-6666

For Research Use Only

Specifications Validation Publications Reviews Featured Products Request SDS/MSDS

Overview

Antibody:

PARG Rabbit anti-Human Polyclonal Antibody

Application:

IF, ELISA

Reactivity:

Human

Format:

Unconjugated, Unmodified

Other formats:

HRP FITC Biotin

Specifications

Description

PARG antibody LS-C501236 is an unconjugated rabbit polyclonal antibody to human PARG. Validated for ELISA and IF.

Target

Human PARG

Synonyms

PARG | PARG99

See All PARG Antibodies

Host

Rabbit

Reactivity

Human (tested or 100% immunogen sequence identity)

Clonality

IgG Polyclonal

Conjugations

Unconjugated. Also available conjugated with HRP, FITC, Biotin.

Purification

Protein G purified

Modifications

Unmodified

Immunogen

Recombinant Human Poly(ADP-ribose) glycohydrolase protein (1-348AA)

Specificity

Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase (PubMed:23102699). PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP-ribose monomers (PubMed:23102699). Required for retinoid acid-dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (PubMed:23102699). Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257).

Applications