Target
Human NLRX1
Synonyms
NLRX1 | CLR11.3 | Caterpiller protein 11.3 | DLNB26 | NLR family member X1 | NLR family, X1 | NOC4L | NOD9 | NOD5 | NOD-like receptor X1 | NOD26
Reactivity
Human
(tested or 100% immunogen sequence identity)
Conjugations
Horseradish Peroxidase.
Also available
Unconjugated or conjugated with
FITC,
Biotin.
Immunogen
Recombinant Human NLR family member X1 protein (45-205AA)
Specificity
Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Has no inhibitory function on NF-Kappa-B and type 1 interferon signaling pathways, but enhances NF-Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313).