Target
NDV / Newcastle Disease Virus
Reactivity
Virus
(tested or 100% immunogen sequence identity)
Immunogen
Glycoprotein hemagglutinin-neuraminidase of Newcastle Disease Virus (La-Sota strain).
Specificity
Detects the La-Sota strain of the Newcastle Disease Virus (NDV), a highly contagious avian virus which is of major economic importance to the poultry industry. NDV is a member of the Paramyxoviridae family, and has a single stranded, negative sense RNA genome. NDV infects via mucosal surfaces of the respiratory and alimentary tract, and its strains can be categorized in accordance to their virulence, from low virulence and mild symptoms (lentogenic), to intermediate forms (mesogenic), through to highly virulent (velogenic) strains which can cause up to 90% mortality. La-Sota is a lentogenic strain, and can be used as a live vaccine. NDV has been reported to selectively kill human tumor cells in a number of clinical studies. Maybe used to detect the hemagglutinin-neuraminidase protein of Newcastle disease virus in ELISA assays.