Target
Bovine NCR1 / NKP46
Synonyms
NCR1 | CD335 | HNKp46 | NK-p46 | Lymphocyte antigen 94 homolog | NK cell-activating receptor | CD335 antigen | LY94 | NKP46
Reactivity
Bovine
(tested or 100% immunogen sequence identity)
Immunogen
Fusion protein consisting of the extracellular region of bovine CD335.
Specificity
Clone AKS1 is specific for bovine CD335, also known as NKp46 and Natural cytotoxicity triggering receptor 1. CD335 is a type I transmembrane protein, with two extracellular C2-type immunoglobulin-like domains, which functions as an activating receptor. CD335 is expressed by human natural killer cells. The bovine homologue is expressed on bovine NK cells and no expression of CD335 has been detected on B cells, T cells, monocytes or granulocytes. Clone AKS1 is reported to activate lysis of FcgammaR-expressing cell line P815, by IL-2 activated NKp46+ cells.