Human NAK / TBK1

Mouse

Human, Mouse (tested or 100% immunogen sequence identity)

IgG1,k Monoclonal

Unconjugated

Protein G purified

Unmodified

NF-kB (nuclear factor kB) is sequestered in the cytoplasm by IkB family of inhibitory proteins that mask the nuclear localization signal of NF-kB thereby preventing translocation of NF-kB to the nucleus (1). External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Synthesis of IkBa is autoregulated (2). IkB proteins are phosphory.

• Western blot (1 - 2 µg/ml)

Suitable for use in Western Blot. Western Blot: 1-2 ug/ml.

PBS, 0.05% Sodium Azide, 0.05% BSA

Short term: store at 4°C. Long term: aliquot and store at -20°C. Avoid freeze-thaw cycles.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: Q9UHD2 NCBI: NM_013254 NP_037386.1