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NACC1 / NAC1
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines.
| Gene Name: | nucleus accumbens associated 1, BEN and BTB (POZ) domain containing |
| Synonyms: | NACC1, BTBD30, BEN domain containing 8, NAC1, Transcriptional repressor NAC1, BEND8, BTBD14B, NAC-1 |
| Target Sequences: | NM_052876 NP_443108.1 Q96RE7 |
Publications (7)
1
A BTB/POZ protein, NAC-1, is related to tumor recurrence and is essential for tumor growth and survival. Nakayama K, Nakayama N, Davidson B, Sheu JJ, Jinawath N, Santillan A, Salani R, Bristow RE, Morin PJ, Kurman RJ, Wang TL, Shih IeM. Proceedings of the National Academy of Sciences of the United States of America. 2006 103:18739-44.
[PubMed:17130457]
[PMC:PMC1693732]
2
Amplification of the ch19p13.2 NACC1 locus in ovarian high-grade serous carcinoma. Shih IeM, Nakayama K, Wu G, Nakayama N, Zhang J, Wang TL. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2011 24:638-45. (IHC; Human)
[PubMed:21240255]
[PMC:PMC3085564]
3
Cell cycle-dependent alteration in NAC1 nuclear body dynamics and morphology. Wu PH, Hung SH, Ren T, Shih IeM, Tseng Y. Physical biology. 2011 8:15005.
[PubMed:21301057]
[PMC:PMC3164573]
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Antibodies
(21)
Proteins
(2)
Type
Over-Expression Lysate
(2)
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(21)
Target
NACC1 / NAC1
(23)
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Human
(19)
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(9)
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(5)
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(3)
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(3)
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(6)
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(3)
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(3)
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IHC
(8)
IHC-P
(9)
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(17)
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(1)
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(1)
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(1)
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rabbit
(19)
mouse
(2)
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(1)
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(11)
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(2)
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monoclonal mc
(2)
polyclonal pc
(19)
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(2)
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(2)
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(2)
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(2)
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(2)
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(15)
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(5)
aa252-301
(4)
aa324-358
(1)
aa355-390
(1)
Publications
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(23)
Tag
Myc-DDK (Flag)
(2)
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Human
(1)
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293T Cells
(1)
HEK 293 Cells
(1)
NACC1 / NAC1 Mouse anti-Human Monoclonal (6H2) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µl/$435
NACC1 / NAC1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$397
NACC1 / NAC1 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Human, Monkey, Chimpanzee
IHC, IHC-P, WB
HRP Conjugated
100 µl/$442
NACC1 / NAC1 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Human, Monkey, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$442
NACC1 / NAC1 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Human, Monkey, Chimpanzee
IHC, IHC-P, WB
FITC Conjugated
100 µl/$442
NACC1 / NAC1 Rabbit anti-Human Polyclonal (aa324-358) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
200 µl/$460
NACC1 / NAC1 Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ICC, IF
Unconjugated, Preservative Free
100 µl/$412
NACC1 / NAC1 Mouse anti-Human Monoclonal (6H2) Antibody
Human
IHC, WB
Unconjugated
100 µl/$541
NACC1 / NAC1 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P
Unconjugated
100 µl/$412
NACC1 / NAC1 Rabbit anti-Human Polyclonal (aa355-390) Antibody
Mouse
Peptide-ELISA, WB
Unconjugated
400 µl/$393
NACC1 / NAC1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
NACC1 / NAC1 Rabbit anti-Human Polyclonal Antibody
Rat, Human
WB
Unconjugated
100 µl/$688
NACC1 / NAC1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$688
NACC1 / NAC1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
NACC1 / NAC1 Rabbit anti-Human Polyclonal (aa252-301) Antibody
Human
WB
Unconjugated
100 µl/$424
NACC1 / NAC1 Rabbit anti-Human Polyclonal (aa252-301) (HRP) Antibody
Xenopus, Bat, Mouse, Dog, Guinea pig, Bovine, Rat, Hamster, Pig, Horse, Chimpanzee, Human, Gibbon
WB
HRP Conjugated
100 µl/$469
NACC1 / NAC1 Rabbit anti-Human Polyclonal (aa252-301) (Biotin) Antibody
Xenopus, Bat, Mouse, Dog, Guinea pig, Bovine, Rat, Hamster, Pig, Horse, Chimpanzee, Human, Gibbon
WB
Biotin Conjugated
100 µl/$469
NACC1 / NAC1 Rabbit anti-Human Polyclonal (aa252-301) (FITC) Antibody
Xenopus, Bat, Mouse, Dog, Guinea pig, Bovine, Rat, Hamster, Pig, Horse, Chimpanzee, Human, Gibbon
WB
FITC Conjugated
100 µl/$469
NACC1 / NAC1 Rabbit anti-Mouse Polyclonal (Preservative Free) Antibody
Mouse
IHC-P
Unconjugated, Preservative Free
100 µl/$412
NACC1 / NAC1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
NACC1 / NAC1 Rabbit anti-Human Polyclonal Antibody
Human
IHC-P
Unconjugated
100 µl/$412
293T Cells
Myc-DDK (Flag)
57.3 kDa
20 µg/$150
HEK 293 Cells
Myc-DDK (Flag)
57.3 kDa
100 µg/$494
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