Target
Human MED23 / SUR2
Synonyms
MED23 | CRSP133 | CRSP130 | CRSP complex subunit 3 | DRIP130 | HSur-2 | KIAA1216 | Protein sur-2 homolog | SUR2 | MRT18 | ARC130 | SUR-2 | CRSP3 | Mediator complex subunit 23
Reactivity
Human
(tested or 100% immunogen sequence identity)
Immunogen
Recombinant Human Mediator of RNA polymerase II transcription subunit 23 protein (1014-1368AA)
Specificity
Required for transcriptional activation subsequent to the assembly of the pre-initiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling.