Target
Human MBOAT5 / C3F
Synonyms
LPCAT3 | Lpcat | LPLAT 5 | MBOAT5 | LPSAT | Lyso-PC acyltransferase | Nessy | C3F | Lyso-PC acyltransferase 3 | Lyso-PS acyltransferase | OACT5
Reactivity
Human
(tested or 100% immunogen sequence identity)
Immunogen
Recombinant human Lysophospholipid acyltransferase 5 protein (306-363AA)
Specificity
Acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (LPCAT activity). Catalyzes also the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) into phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine or PS) (LPSAT activity). Has also weak lysophosphatidylethanolamine acyltransferase activity (LPEAT activity). Favors polyunsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs. Seems to be the major enzyme contributing to LPCAT activity in the liver. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle.