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The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins.
Gene Name: | mitogen-activated protein kinase 8 interacting protein 2 |
Synonyms: | MAPK8IP2, Homologous to mouse JIP-1, Islet-brain-2, JNK-interacting protein 2, IB-2, IB2, Islet-brain 2, PRKM8 interacting protein-like, JIP-2, JIP2, PRKM8IPL |
Target Sequences: | NM_012324 NP_036456.1 Q13387 |
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